Spectrofluorometric determination of alkoxy-substituted benzylimidazolidinones in biological fluids.
J Pharm Sci
; 67(6): 752-6, 1978 Jun.
Article
en En
| MEDLINE
| ID: mdl-660447
Sensitive and specific spectrofluorometric assays were developed for the determination of d, 1-4-(3,4-dimethoxybenzyl)-2-imidazolidinone and d,1-4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone in blood and urine. Each compound is selectively extracted from buffered blood or urine and oxidized with alkaline permanganate to its respective fluorescent benzoic acid derivative, which is quantitated in acetic acid in ethanol (1:99). The method was applied to the determination of blood levels and urinary excretion in the dog following the administration of single intravenous and oral doses of each compound.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Imidazoles
Límite:
Animals
Idioma:
En
Revista:
J Pharm Sci
Año:
1978
Tipo del documento:
Article
Pais de publicación:
Estados Unidos