RESUMEN

This study reports on the chemical composition and antileishmanial and anticandidal activities of volatile oils (VOs) of Schinus molle dried leaves (SM), Cinnamomum cassia branch bark (CC) and their blends. Major constituents of SM were spathulenol (26.93 %), ß-caryophyllene (19.90 %), and caryophyllene oxide (12.69 %), whereas (E)-cinnamaldehyde (60.11 %), cinnamyl acetate (20.90 %) and cis-2-methoxycinnamic acid (10.37 %) were predominant in CC. SM (IC50=21.45 µg/mL) and CC (IC50=23.27 µg/mL) displayed good activity against L. amazonensis promastigotes, besides having good or moderate activity against nine Candida strains, with Minimum Inhibitory Concentration (MIC) values ranging from 31.25 to 250 µg/mL. While the three SM and CC blends were not more active than the VOs tested individually, they exhibited remarkably high antileishmanial activity, with IC50 values ranging between 3.12 and 7.04 µg/mL, which is very similar to the IC50 of amphotericin B (positive control).

Asunto(s)

Anacardiaceae , Antifúngicos , Antiprotozoarios , Cinnamomum aromaticum , Pruebas de Sensibilidad Microbiana , Aceites Volátiles , Corteza de la Planta , Hojas de la Planta , Antifúngicos/farmacología , Antifúngicos/química , Antifúngicos/aislamiento & purificación , Hojas de la Planta/química , Corteza de la Planta/química , Cinnamomum aromaticum/química , Aceites Volátiles/farmacología , Aceites Volátiles/química , Aceites Volátiles/aislamiento & purificación , Anacardiaceae/química , Antiprotozoarios/farmacología , Antiprotozoarios/química , Antiprotozoarios/aislamiento & purificación , Leishmania/efectos de los fármacos , Candida/efectos de los fármacos , Pruebas de Sensibilidad Parasitaria , Animales , Relación Estructura-Actividad , Relación Dosis-Respuesta a Droga , Schinus