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Antileishmanial and Antifungal Activities of Volatile Oils from Cinnamomum Cassia Bark and Schinus Molle Leaves.
da Silva, Aternoskaires S R; Fernandes, Cassia C; Dos Santos, Daiane A; Mazza, Marya C M; Silva, Jackson B A; Magalhães, Lizandra G; Pires, Regina H; Miranda, Mayker L D; Crotti, Antônio E M.
Afiliación
  • da Silva ASR; Instituto Federal de Educação, Ciência e Tecnologia Goiano, Campus Rio Verde, 75.901-970, Rio Verde, GO, Brazil.
  • Fernandes CC; Instituto Federal de Educação, Ciência e Tecnologia Goiano, Campus Rio Verde, 75.901-970, Rio Verde, GO, Brazil.
  • Dos Santos DA; Universidade de Franca, CEP, 14404-600, Franca, SP, Brazil.
  • Mazza MCM; Universidade de Franca, CEP, 14404-600, Franca, SP, Brazil.
  • Silva JBA; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, SP-14040-901, Ribeirão Preto, Brazil.
  • Magalhães LG; Universidade de Franca, CEP, 14404-600, Franca, SP, Brazil.
  • Pires RH; Universidade de Franca, CEP, 14404-600, Franca, SP, Brazil.
  • Miranda MLD; lnstituto Federal de Educação, Ciência e Tecnologia do Triângulo Mineiro, Campus Uberlândia, Centro, CEP, MG-38411-104, Uberlândia, Brazil.
  • Crotti AEM; Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, SP-14040-901, Ribeirão Preto, Brazil.
Chem Biodivers ; : e202401076, 2024 Jun 20.
Article en En | MEDLINE | ID: mdl-38899851
ABSTRACT
This study reports on the chemical composition and antileishmanial and anticandidal activities of volatile oils (VOs) of Schinus molle dried leaves (SM), Cinnamomum cassia branch bark (CC) and their blends. Major constituents of SM were spathulenol (26.93 %), ß-caryophyllene (19.90 %), and caryophyllene oxide (12.69 %), whereas (E)-cinnamaldehyde (60.11 %), cinnamyl acetate (20.90 %) and cis-2-methoxycinnamic acid (10.37 %) were predominant in CC. SM (IC50=21.45 µg/mL) and CC (IC50=23.27 µg/mL) displayed good activity against L. amazonensis promastigotes, besides having good or moderate activity against nine Candida strains, with Minimum Inhibitory Concentration (MIC) values ranging from 31.25 to 250 µg/mL. While the three SM and CC blends were not more active than the VOs tested individually, they exhibited remarkably high antileishmanial activity, with IC50 values ranging between 3.12 and 7.04 µg/mL, which is very similar to the IC50 of amphotericin B (positive control).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza