RESUMEN
Transdermal therapeutic systems (TTS) gain continuously increasing importance in therapy due to their advantageous properties. They assure constant concentration of the active substance in the blood, a lower amount of the drug compared to the orally administered dose is sufficient, side effects decrease, and the therapy is painless. Since the appearance of the first products many TTSs have been developed containing a wide variety of active substances including hormonal, antihypertensive, antianginal, and analgesic plasters. Nowadays TTSs belong to the most advanced formulations. There is ongoing research in the field of regulating the active substance release with electric current or ultrasound. There are systems containing insulin, cytostatics, antiparkinsonians, contraceptives, and anxiolytics under development.
Asunto(s)
Analgésicos/administración & dosificación , Antihipertensivos/administración & dosificación , Cardiotónicos/administración & dosificación , Hormonas/administración & dosificación , Administración Cutánea , Química Farmacéutica/métodos , HumanosRESUMEN
Our first project aimed at the determination of the average values of Mg in normal human brain (20 individuals, mean age 70 years). Ten brain parts were selected from both hemispheres. Determinations were carried out by inductively coupled plasma atomic emission spectrometry, inductively coupled plasma mass spectrometry and instrumental neutron activation analysis methods. In order to investigate the precision and the accuracy of the methods five biological standard reference materials were analyzed. The present results show a non-homogeneous distribution of Mg in normal human brain. Regions corresponding to each other in both hemispheres show almost identical concentration. The second goal was to study the possible Mg concentration changes in Alzheimer's disease (nine patients, ten brain parts). Mg values are found to be significantly decreased in brain regions of diseased patients compared to the controls.