Disturbances of magnesium concentrations in various brain areas in Alzheimer's disease.
Magnes Res
; 13(3): 189-96, 2000 Sep.
Article
en En
| MEDLINE
| ID: mdl-11008926
Our first project aimed at the determination of the average values of Mg in normal human brain (20 individuals, mean age 70 years). Ten brain parts were selected from both hemispheres. Determinations were carried out by inductively coupled plasma atomic emission spectrometry, inductively coupled plasma mass spectrometry and instrumental neutron activation analysis methods. In order to investigate the precision and the accuracy of the methods five biological standard reference materials were analyzed. The present results show a non-homogeneous distribution of Mg in normal human brain. Regions corresponding to each other in both hemispheres show almost identical concentration. The second goal was to study the possible Mg concentration changes in Alzheimer's disease (nine patients, ten brain parts). Mg values are found to be significantly decreased in brain regions of diseased patients compared to the controls.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Química Encefálica
/
Enfermedad de Alzheimer
/
Magnesio
Límite:
Aged
/
Aged80
/
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Magnes Res
Asunto de la revista:
FARMACOLOGIA
/
METABOLISMO
/
TERAPIA POR MEDICAMENTOS
Año:
2000
Tipo del documento:
Article
País de afiliación:
Hungria
Pais de publicación:
Reino Unido