RESUMEN
Antiviral and interferon inducing activity of the amixine and its some derivatives, as well as their influence on the proteolytic enzymes activity, monooxygenase activity of the microsomal fraction, level of the lipids peroxidation were studied. Lack of correlation between antiviral and interferon inducing activity in the investigated series of compounds was found. Vice versa, the good correlation between interferon inducing activity and the elastase-like activities inhibition ability of the compounds was observed. It allows to state the assumption, that only one ability of compounds to induce of an interferon doesn't suffice for obtaining of high titres of interferon, and while their rather high antiproteolitic activity is necessary. It's shown, that except for one compound the influence of amixine and its derivatives on the red-ox enzymes activity well correlates with their ability to the interferon-inducing. All presented above allows to attribute amixine and its derivatives to polymodal antiviral agents.
Asunto(s)
Antivirales/farmacología , Inductores de Interferón/farmacología , Tilorona/farmacología , Animales , Antivirales/metabolismo , Inductores de Interferón/metabolismo , Ratones , Oxidación-Reducción , Tilorona/metabolismoRESUMEN
Nine bis-acridine derivatives have been synthesized in search of structures with antiviral properties. Synthesis of target compounds was provided by a standard peptide-like coupling procedure using aliphatic diamines and protected amino acids following protective group removing and acridinylation by means of 9-methoxyacridine. Two out of nine compounds tested demonstrate high protective activity of Vero cells against HSV infection. Antiviral activity was observed only for compounds containing a pentamethylene fragment as a linker. The alanyl-containing derivative was less active than those containing valyl- and phenylalanyl. Most of synthesized compounds were less toxic than N,N'-bis-(acridinyl) hexamethylenediamine.
Asunto(s)
Acridinas/síntesis química , Antivirales/síntesis química , Acridinas/farmacología , Animales , Antivirales/farmacología , Chlorocebus aethiops , Sustancias Intercalantes/farmacología , Pruebas de Sensibilidad Microbiana , Simplexvirus/efectos de los fármacos , Células VeroAsunto(s)
Aminoácidos/síntesis química , Antineoplásicos/síntesis química , Aminoácidos/farmacología , Antineoplásicos/farmacología , División Celular/efectos de los fármacos , Fenómenos Químicos , Química Física , Células Vegetales , Raíces de Plantas/química , Plantas/efectos de los fármacos , Plantas Medicinales/químicaAsunto(s)
Aminoacridinas/síntesis química , Antivirales/síntesis química , Aminoacridinas/farmacología , Animales , Antivirales/farmacología , Infecciones por Bunyaviridae/prevención & control , Infecciones por Bunyaviridae/virología , Fenómenos Químicos , Química Física , Ratones , ARN Viral/efectos de los fármacos , Fiebre del Valle del Rift/prevención & control , Fiebre del Valle del Rift/virologíaRESUMEN
The morbidity was studied of 3000 preschool children born and inhabiting the territory of six Rovno Province districts belonging to the "Western trail" of the Chernobyl accident. It was found that the children born in 1986-1987 showed a 1.5-3 times increase of the morbidity as compared with the pre-accident period.
Asunto(s)
Accidentes de Trabajo , Contaminación Radiactiva del Aire/efectos adversos , Exposición a Riesgos Ambientales/efectos adversos , Morbilidad , Reactores Nucleares , Centrales Eléctricas , Accidentes de Trabajo/estadística & datos numéricos , Distribución por Edad , Contaminación Radiactiva del Aire/estadística & datos numéricos , Preescolar , Exposición a Riesgos Ambientales/estadística & datos numéricos , Femenino , Humanos , Incidencia , Masculino , Ucrania/epidemiologíaRESUMEN
Altogether 225 patients with transitory derangements of cerebral circulation (TDCC) underwent clinico-laboratory examinations. Arterial hypertension and cerebral atherosclerosis turned out to be among most frequently occurring factors of TDCC. The provoking factors included psychoemotional stress and drops of barometric pressure. The course and outcome of TDCC were greatly affected by an increase in blood concentration of catecholamines and thyroid hormones. The high concentration of triiodothyronine in the blood contributed to the development of cerebral stroke.
Asunto(s)
Altitud , Ataque Isquémico Transitorio/etiología , Adulto , Anciano , Mal de Altura/complicaciones , Femenino , Humanos , Hipertensión/complicaciones , Hipertiroidismo/complicaciones , Arteriosclerosis Intracraneal/complicaciones , Ataque Isquémico Transitorio/epidemiología , Masculino , Persona de Mediana Edad , Ucrania/epidemiologíaRESUMEN
The article provides research data on the age-related peculiarities of morbidity and reviews issues pertaining to the quality of medical services for the older age groups of workers including the rational use of drug therapy. Specified are the requirements of this particular age group in special medical care. A major aspect in the improvement of health care for workers beyond forty lies in substantial geriatric training of shop physicians.
Asunto(s)
Instituciones de Atención Ambulatoria/normas , Servicios de Salud del Trabajador/normas , Medicina del Trabajo/normas , Factores de Edad , Instituciones de Atención Ambulatoria/organización & administración , Humanos , Persona de Mediana Edad , Servicios de Salud del Trabajador/organización & administración , Calidad de la Atención de Salud , Ucrania , Evaluación de Capacidad de TrabajoRESUMEN
Modifying effects of widely used immunomodulator tylorone on lipid peroxidation and the state of antioxidant system were studied under conditions of normal state as well as in subacute poisoning with carbon monooxide. Multiple effects of tylorone on these reactions were found in various tissues. The drug increased content of reduced glutathione in liver tissue, while amount of the substance was decreased in kidney and heart muscle. Content of diene conjugates and of SH-groups in blood, content of ascorbate in adrenal glands and activity of glucose-6-phosphate dehydrogenase in liver tissue were found to decrease. After administration of tylorone alterations of the most patterns studied under hypoxic conditions were similar to those of normal state. At the same time, the oppositely directed alterations were detected in content of reduced glutathione in heart muscle and in activity of glucose-6-phosphate dehydrogenase in liver tissue under conditions of carbon monoxide poisoning.
Asunto(s)
Fluorenos/farmacología , Hipoxia/metabolismo , Peroxidación de Lípido/efectos de los fármacos , Tilorona/farmacología , Animales , Radicales Libres , Hipoxia/prevención & control , Masculino , Ratones , Ratones Endogámicos CBA , Oxidación-Reducción , RatasAsunto(s)
Inmunoterapia , Leucemia Linfoide/etiología , Anciano , Femenino , Humanos , Inmunidad Celular/efectos de los fármacos , Leucemia Linfoide/inmunología , Leucemia Linfoide/terapia , Recuento de Leucocitos/efectos de los fármacos , Levamisol/farmacología , Levamisol/uso terapéutico , Masculino , Persona de Mediana Edad , Formación de Roseta , Tilorona/farmacología , Tilorona/uso terapéuticoRESUMEN
The immune system state was studied before and after administration of tilorone (an immunologic adjuvant) to guinea pigs with synestrol-induced glandular hyperplasia of endometrium. The total amount of T- and B-lymphocytes. T-lymphocytes with receptors to the Fc-fragment of IgM and IgG, the content of immune complexes were determined. Immune and nonimmune adherence of neutrophils was investigated as well. It was established that the total amount of T-lymphocytes decreased and the quantity of T-lymphocytes and immune complexes increased with the development of glandular hyperplasia of the endometrium. The tilorone administration normalized the structure of endometrium and T-lymphocyte immune controlling system.
Asunto(s)
Dienestrol/toxicidad , Hiperplasia Endometrial/tratamiento farmacológico , Fluorenos/uso terapéutico , Fenoles/toxicidad , Tilorona/uso terapéutico , Animales , Complejo Antígeno-Anticuerpo/análisis , Linfocitos B/efectos de los fármacos , Linfocitos B/inmunología , Hiperplasia Endometrial/inducido químicamente , Hiperplasia Endometrial/inmunología , Femenino , Cobayas , Receptores Fc/análisis , Linfocitos T/efectos de los fármacos , Linfocitos T/inmunologíaRESUMEN
It is established that tilorone-hydrochloride, the antiviral agent, stimulating the interferon synthesis in the organism of animals under experiment inhibits monooxygenase reactions in the albino rat hepatocytes being administered in combination with phenobarbital and 20-methylcholanthrene. The tilorone effect on the N- and O-demethylase activity of the liver microsomes in vitro was studied. It is established that the rate of dimethylaniline N-demethylation and anisole O-demethylation in this case lowers considerably, the character of the kinetic curves being unchanged.
Asunto(s)
Fluorenos/farmacología , Inductores de Interferón/farmacología , Microsomas Hepáticos/enzimología , Oxigenasas de Función Mixta/metabolismo , Tilorona/farmacología , Animales , Femenino , Cinética , Hígado/efectos de los fármacos , Metilcolantreno/farmacología , Microsomas Hepáticos/efectos de los fármacos , Fenobarbital/farmacología , RatasRESUMEN
The functional state of the thyroid gland was studied in 160 patients with different forms of disturbed cerebral circulation. The observations included studies of the iodine content and its fractions in the blood serum and a scanning of the thyroid gland. The author established the significance of thyroid gland dysfunction in the pathogenesis of hypertensive disease and cerebro-vascular insufficiency. In patients with hypertensive crises these studies detected the existence of a hyperthyroid syndrome. It was also found that in patients with cerebrovascular insufficiency accompanied by thyroid gland dysfunctions the clinical picture becomes more aggravated.