[The effect of tilorone on peroxidation systems and antiperoxidation defense under normal conditions and in hypoxia]. / Vliianie tilorona na sistemy perekisnogo okisleniia i antiperekisnoi zashchity v norme i pri gipoksii.
Vopr Med Khim
; 36(1): 60-2, 1990.
Article
en Ru
| MEDLINE
| ID: mdl-2343579
Modifying effects of widely used immunomodulator tylorone on lipid peroxidation and the state of antioxidant system were studied under conditions of normal state as well as in subacute poisoning with carbon monooxide. Multiple effects of tylorone on these reactions were found in various tissues. The drug increased content of reduced glutathione in liver tissue, while amount of the substance was decreased in kidney and heart muscle. Content of diene conjugates and of SH-groups in blood, content of ascorbate in adrenal glands and activity of glucose-6-phosphate dehydrogenase in liver tissue were found to decrease. After administration of tylorone alterations of the most patterns studied under hypoxic conditions were similar to those of normal state. At the same time, the oppositely directed alterations were detected in content of reduced glutathione in heart muscle and in activity of glucose-6-phosphate dehydrogenase in liver tissue under conditions of carbon monoxide poisoning.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tilorona
/
Peroxidación de Lípido
/
Fluorenos
/
Hipoxia
Límite:
Animals
Idioma:
Ru
Revista:
Vopr Med Khim
Año:
1990
Tipo del documento:
Article
Pais de publicación:
Rusia