1.
Bioorg Med Chem Lett
; 27(21): 4838-4843, 2017 11 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-28985999
RESUMEN
Discovery of potent renin inhibitors which contain a simplified alkylamino Asp-binding group and exhibit improved selectivity for renin over Cyp3A4 is described. Structure-function results in this series are rationalized based on analysis of selected compounds bound to renin, and the contribution of each molecular feature leading to the reduced P450 inhibition is quantified.