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Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition.
Lawhorn, Brian G; Tran, Tritin; Hong, Victor S; Morgan, Lisa A; Le, BaoChau T; Harpel, Mark R; Jolivette, Larry; Diaz, Elsie; Schwartz, Benjamin; Gross, Jeffrey W; Tomaszek, Thaddeus; Semus, Simon; Concha, Nestor; Smallwood, Angela; Holt, Dennis A; Kallander, Lara S.
Afiliación
  • Lawhorn BG; Heart Failure DPU, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA. Electronic address: brian.2.lawhorn@gsk.com.
  • Tran T; Heart Failure DPU, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.
  • Hong VS; Heart Failure DPU, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.
  • Morgan LA; Heart Failure DPU, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.
  • Le BT; Heart Failure DPU, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.
  • Harpel MR; Heart Failure DPU, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.
  • Jolivette L; Heart Failure DPU, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.
  • Diaz E; Platform Sciences and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  • Schwartz B; Platform Sciences and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  • Gross JW; Platform Sciences and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  • Tomaszek T; Platform Sciences and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  • Semus S; Platform Sciences and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  • Concha N; Platform Sciences and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  • Smallwood A; Platform Sciences and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  • Holt DA; Heart Failure DPU, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.
  • Kallander LS; Heart Failure DPU, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.
Bioorg Med Chem Lett ; 27(21): 4838-4843, 2017 11 01.
Article en En | MEDLINE | ID: mdl-28985999
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Renina / Ácido Aspártico / Citocromo P-450 CYP3A Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Renina / Ácido Aspártico / Citocromo P-450 CYP3A Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido