RESUMEN
Optical quality GaSe crystals have been grown by vertical Bridgman method. The structural properties and micromorphology of a cleaved GaSe(001) surface have been evaluated by RHEED, SEM and AFM. The cleaved GaSe(001) is atomically flat with as low roughness as â¼0.06 nm excepting local hillock type defects. The hillock-type formations are round-shaped with a bottom diameter of â¼200 nm and a height of â¼20-35 nm. The drastic depletion of the hillock material by gallium has been indicated by EDX measurements.
RESUMEN
The authors have developed the 4-level system for restoration of operator's professional vision basing on the principles of conception's project of health protection in Russian Federation. On the hole the complex system of sanitary measures includes the following directions: the wide use of self-prophylaxis and correction methods of visual disorders, the purposeful use of effective means of visual profile ("operative correction") directly in the operator's working place, as well as the conduction of complex stimulation of vision organ on the basis of specialized room ("long-term correction").
Asunto(s)
Oftalmopatías/rehabilitación , Centros de Rehabilitación/organización & administración , Centros de Rehabilitación/tendencias , Humanos , Federación de RusiaRESUMEN
The authors describe a physiotherapeutic technique of functional stimulation of the organ of vision which allows effective prevention and correction of functional manifestations of visual asthenia syndrome in persons with normal visual status. The effectiveness of the technique was proved by improvement in clinical (sight acuteness, accommodation reserves), functional and subjective (visual life quality) parameters of the visual analyzer function.
Asunto(s)
Modalidades de Fisioterapia , Trastornos de la Visión/terapia , Acomodación Ocular , Humanos , Terapia por Láser , Encuestas y Cuestionarios , Trastornos de la Visión/rehabilitación , Agudeza VisualRESUMEN
A derivative of pyrazinocarbazole the antidepressant pyrazidol, whose inhibition of serotonin deaminase activity of the brain mitochondrial monoamine oxidase is attended by induction of the property of catalysing histamine oxidation, inhibits the growth of glial tumors in experiments. Another derivative of pyrazinocarbazole, which inhibits serotonin deamination but does not induce the appearance of histamine deaminase activity, produces no effect on the growth of glial tumors of the brain.
Asunto(s)
Astrocitoma/tratamiento farmacológico , Neoplasias Encefálicas/tratamiento farmacológico , Encéfalo/efectos de los fármacos , Glioma/tratamiento farmacológico , Mitocondrias/efectos de los fármacos , Monoaminooxidasa/efectos de los fármacos , Animales , Antineoplásicos/uso terapéutico , Astrocitoma/enzimología , Encéfalo/enzimología , Neoplasias Encefálicas/enzimología , Carbazoles/uso terapéutico , Catálisis/efectos de los fármacos , Ensayos de Selección de Medicamentos Antitumorales , Glioma/enzimología , Mitocondrias/enzimología , Monoaminooxidasa/metabolismo , Inhibidores de la Monoaminooxidasa/uso terapéutico , Trasplante de Neoplasias , Ratas , Ratas EndogámicasRESUMEN
The disodium salt of 2,6-dimethyl-1,4-dihydropyridine-3,5-bis-carbonyl hydroxyacetic acid (I) used in the mg/kg dose decreases the cyclophosphane toxicity in mice and potentiates the cytostatic activity of cyclophosphane, 5-fluorouracil and arabinosyl cytosine against leukemia P388, murine sarcoma 37 and Walker's carcinosarcoma. Administered alone I exhibits no antitumour activity. The potentiation of the antitumour effect of drugs appears independent of the administration schedule. Biochemical evidence indicates that I does not block DNA synthesis in leukemic cells in vitro, but significantly enhances the DNA-blocking effect of cyclophosphane in the same cells in vivo.
Asunto(s)
Antineoplásicos/farmacología , Dihidropiridinas , Neoplasias Experimentales/tratamiento farmacológico , Piridinas/farmacología , Animales , Antineoplásicos/administración & dosificación , Antineoplásicos/toxicidad , Células Cultivadas , ADN de Neoplasias/biosíntesis , Sinergismo Farmacológico , Dosificación Letal Mediana , Leucemia P388/tratamiento farmacológico , Leucemia P388/metabolismo , Masculino , Ratones , Neoplasias Experimentales/metabolismo , Piridinas/administración & dosificación , Piridinas/toxicidad , Sarcoma 37/tratamiento farmacológico , Sarcoma 37/metabolismoRESUMEN
Biotransformation of ftorafir (FT) was studied using 2-14C-ftorafur and 2;5'-14C-ftorafur. Both pyrimidine and tetrahydrofurane moieties of the FT underwent degradation to CO2 in rats. The cleavage of the pseudoglycosidic bonds C-N and formation of 5-fluorouracil was one of the steps of the FT metabolism that limited the velocity of the whole biotransformation process. Liver tissue NADPH-linked monooxygenating system was shown to participate in the process. The data obtained suggest that the role of enzymes involved in metabolism of nucleic acids was not significant in the FT metabolism under the conditions studied in vivo.
Asunto(s)
Fluorouracilo/análogos & derivados , Tegafur/metabolismo , Animales , Biotransformación , Radioisótopos de Carbono , Cinética , Hígado/enzimología , Masculino , Oxigenasas de Función Mixta/metabolismo , NADP , RatasRESUMEN
The pharmacokinetics of phthorafur-2-14C (Ph) was investigated after its intravenous injection to rats with Walker carcinosarcoma. The blood plasma level of Ph-2-14C and its metabolites proved to decrease in to a three-phase process. The content of the agent in the tissues decreased in the following sequence: the kidney, small intestine, tumour, stomach, muscle, heart, liver, lungs, spleen, brain and fat. The tumour was observed to contain Ph-2-14C and endogenous metabolite 5-phthoruracil-2-14C. Excretion of the agent continued for 48 hrs, 52.2% of the administered dose being eliminated via the urinary tract, 30% as 14CO2, and 0.8% in feces.