RESUMEN
Our prospective hospital-based study examined frequency, clinical presentation and serological indicators of coeliac disease that correlated with intestinal biopsy among high-risk Sudanese children. From July 2001 to July 2002, 80 children aged 15 months-18 years presented with poor appetite, weight loss, pallor and proximal muscle wasting. We diagnosed coeliac disease in 18 (22.5%). Antigliadin antibodies (AGA-IgG, AGA-IgA or both) were high in 44; endomysial antibody retest was high in 30. Guardians of 12 children refused consent for biopsy. The other 18 were biopsied: 5 had total villous atrophy, 8 subtotal and 5 partial. All improved with gluten-free diet. Degree of villous atrophy did not correlate with diarrhoea duration or severity, anaemia severity or serological titres.
Asunto(s)
Enfermedad Celíaca/diagnóstico , Enfermedad Celíaca/epidemiología , Anorexia/etiología , Biopsia , Enfermedad Celíaca/sangre , Enfermedad Celíaca/complicaciones , Enfermedad Celíaca/inmunología , Niño , Preescolar , Diarrea/etiología , Ensayo de Inmunoadsorción Enzimática , Femenino , Gliadina/inmunología , Humanos , Inmunoglobulina A/sangre , Inmunoglobulina G/sangre , Incidencia , Lactante , Masculino , Tamizaje Masivo/métodos , Atrofia Muscular/etiología , Palidez/etiología , Vigilancia de la Población , Estudios Prospectivos , Factores de Riesgo , Estudios Seroepidemiológicos , Factores Socioeconómicos , Sudán/epidemiologíaRESUMEN
Our prospective hospital- based study examined frequency, clinical presentation and serological indicators of coeliac disease that correlated with intestinal biopsy among high- risk Sudanese children. From July 2001 to July 2002, 80 children aged 15 months- 18 years presented with poor appetite, weight loss, pallor and proximal muscle wasting. We diagnosed coeliac disease in 18 [22.5%]. Antigliadin antibodies [AGA- IgG, AGA- IgA or both] were high in 44; endomysial antibody retest was high in 30. Guardians of 12 children refused consent for biopsy. The other 18 were biopsied: 5 had total villous atrophy, 8 subtotal and 5 partial. All improved with gluten- free diet. Degree of villous atrophy did not correlate with diarrhoea duration or severity, anaemia severity or serological titres