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INTRODUCTION: The Human Immunodeficiency Virus (HIV) is one of the greatest public health challenges still facing communities worldwide, and until this moment, no vaccine is available for its prevention. In Brazil, the Rio de Janeiro State has stood out regarding the prevalence of this disease. As a result, an important state to consider the Willingness to Pay (WTP) for a hypothetical HIV vaccine to help with future pricing. METHODS: A cross-sectional study was conducted to assess the acceptability and WTP of individuals from Rio de Janeiro State for a hypothetical HIV vaccine with a 70% efficacy. RESULTS: 600 individuals were interviewed and the acceptability for this hypothetical vaccine was 77.2%. In addition, 452 participants were eligible for the WTP analysis and would accept a WTP US$79.37 (400 BRL) for this vaccine, a higher value than that found in another study (200 BRL) conducted in the Northern region of Brazil under the same methodological conditions. CONCLUSION: Economic studies such as WTP can contribute to discussions regarding the prices and specifications for future vaccines, particularly for a HIV vaccine in countries such as Brazil with over 5,000 municipalities spread across regions with diverse characteristics and challenges in terms of socioeconomic, epidemiological and cultural differences.

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Este é um estudo descritivo que tem como objetivo relatar a experiência vivenciada no projeto de extensão denominado "Educa Mais Trânsito", desenvolvido por discentes e docentes da Faculdade de Saúde Coletiva, da Universidade Federal do Sul e Sudeste do Pará (Unifesspa), idealizado para realizar ações educativas em saúde, no município de Marabá (PA), frente aos muitos acidentes de trânsito na região. No Brasil, o Estado do Pará caracteriza-se como o de maior ocorrência, sendo 6.398 internações e 1.159 óbitos apenas em 2018. Em Marabá, no sudeste do estado, registrou-se 296 acidentes e 76 óbitos no mesmo período. Primeiramente, foram realizadas rodas de conversas envolvendo acadêmicos do curso de Bacharelado em Saúde Coletiva com profissionais que atuam em órgãos ligados a segurança e assistência no trânsito da região. Posteriormente, houve a realização de palestras educativas, peças teatrais (público infantil e jovens), jogos educativos em quatro escolas do município, bem como a realização do I Simpósio de Educação no Trânsito de Marabá. Durante as atividades, observou-se a importância das práticas educativas com foco na promoção da conscientização, sensibilização e mobilização não só de estudantes da região mas, também, do envolvimento deste público com órgãos governamentais no que tange a regulamentação dos eventos do trânsito do município. Neste contexto, reforça-se a importância da parceria universidade e comunidade na formação de cidadãos/ãs conhecedores dos problemas de sua localidade com a sensibilização sobre os sérios problemas de saúde pública como os acidentes de trânsito através de projetos extensionistas.

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Arthropod-borne viruses (arboviruses), such as Zika virus (ZIKV), chikungunya virus (CHIKV), dengue virus (DENV), yellow fever virus (YFV), and West Nile virus (WNV), are pathogens of global importance. Therefore, there has been an increasing need for new drugs for the treatment of these viral infections. In this context, antimicrobial peptides (AMPs) obtained from animal venoms stand out as promising compounds because they exhibit strong antiviral activity against emerging arboviral pathogens. Thus, we systematically searched and critically analyzed in vitro and in vivo studies that evaluated the anti-arbovirus effect of peptide derivatives from toxins produced by vertebrates and invertebrates. Thirteen studies that evaluated the antiviral action of 10 peptides against arboviruses were included in this review. The peptides were derived from the venom of scorpions, spiders, wasps, snakes, sea snails, and frogs and were tested against DENV, ZIKV, YFV, WNV, and CHIKV. Despite the high structural variety of the peptides included in this study, their antiviral activity appears to be associated with the presence of positive charges, an excess of basic amino acids (mainly lysine), and a high isoelectric point (above 8). These peptides use different antiviral mechanisms, the most common of which is the inhibition of viral replication, release, entry, or fusion. Moreover, peptides with virucidal and cytoprotective (pre-treatment) effects were also identified. In conclusion, animal-venom-derived peptides stand out as a promising alternative in the search and development of prototype antivirals against arboviruses.

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Background and objectives: Considering the little evidence associated with dengue hospitalizations, their public expenditures in Southeast Pará and its relevance to the public health in Brazil, this study aims to demonstrate the records of hospitalizations and expenses associated with this arbovirus between 2000 and 2015 from the perspective of the Unified Health System (SUS). Methods: This is a descriptive research that sought to assess the records and expenses (USD) of hospitalization caused by dengue (SUS code: 74500457, 74300440, 0303010010) and severe dengue (SUS code: 74300628, 74500627, 0303010029), as well as their associated deaths (CID: A90 and A91), respectively, from the SIH/SUS and SIM/SUS from 2000 to 2015 for all 39 municipalities in the southeast of Pará. Results: A total of 1206 deaths, 22,860 individuals with dengue and 306 with severe dengue underwent services in the SUS between 2000 and 2015, representing 23,166 hospitalizations (23,613: dengue and 313: severe dengue), in which Bom Jesus do Tocantins and Goianésia do Pará represent the municipalities with the highest number of hospitalizations associated with dengue. Conclusion: It is possible to verify the relevance of continuing efforts to combat and fight dengue in southeastern Pará. It reinforces the need to conduct studies that contribute to a better understanding of the distribution of hospitalizations and deaths in the different municipalities of the state of Pará, as well as reflections on the epidemiological and economic scenario for the implementation of a rational and efficient decision-making process.(AU)

Justificativa e objetivos: Considerando as poucas evidências associadas às internações por dengue, seus gastos públicos no Sudeste do Pará e sua relevância para a saúde pública no Brasil, este estudo tem como objetivo demonstrar os registros de internações e gastos associados a esta arbovirose entre 2000 e 2015 a partir da perspectiva do Sistema Único de Saúde (SUS). Métodos: Trata-se de uma pesquisa descritiva que buscou avaliar os registros e gastos (USD) de internação por dengue (código SUS: 74500457, 74300440, 0303010010) e dengue grave (código SUS: 74300628, 74500627, 0303010029), bem como seus óbitos associados (CID: A90 e A91), respectivamente, do SIH/SUS e SIM/SUS de 2000 a 2015 para todos os 39 municípios do sudeste paraense. Resultados: Um total de 1.206 óbitos, 22.860 indivíduos com dengue e 306 com dengue grave foram atendidos no SUS entre 2000 e 2015, representando 23.166 internações (23.613: dengue e 313: dengue grave), nas quais Bom Jesus do Tocantins e Goianésia do O Pará representa os municípios com maior número de internações associadas à dengue. Conclusão: É possível verificar a relevância da continuidade dos esforços de combate e combate à dengue no sudeste paraense. Reforça a necessidade da realização de estudos que contribuam para um melhor entendimento da distribuição das internações e óbitos nos diferentes municípios do estado do Pará, bem como reflexões sobre o cenário epidemiológico e econômico para a implementação de um processo decisório racional e eficiente. Fazendo processo.(AU)

Justificación y objetivos: Considerando la poca evidencia asociada a las hospitalizaciones por dengue, sus gastos públicos en el Sudeste de Pará y su relevancia para la salud pública en Brasil, este estudio tiene como objetivo demostrar los registros de hospitalizaciones y gastos asociados a este arbovirus entre 2000 y 2015 a partir de la perspectiva del Sistema Único de Salud (SUS). Métodos: Se trata de una investigación descriptiva que buscó evaluar los registros y gastos (USD) de hospitalización por dengue (código SUS: 74500457, 74300440, 0303010010) y dengue grave (código SUS: 74300628, 74500627, 0303010029), así como sus muertes asociadas (CID: A90 y A91), respectivamente, del SIH/SUS y SIM/SUS de 2000 a 2015 para los 39 municipios del sureste de Pará. Resultados: Un total de 1206 muertes, 22.860 personas con dengue y 306 con dengue grave fueron atendidos en el SUS entre 2000 y 2015, lo que representa 23.166 hospitalizaciones (23.613: dengue y 313: dengue grave), en las que Bom Jesus do Tocantins y Goianésia hacen Pará representan los municipios con mayor número de hospitalizaciones asociadas al dengue. Conclusión: Es posible verificar la relevancia de continuar los esfuerzos para combatir y luchar contra el dengue en el sureste de Pará. Refuerza la necesidad de realizar estudios que contribuyan a una mejor comprensión de la distribución de hospitalizaciones y muertes en los diferentes municipios del estado de Pará, así como reflexiones sobre el escenario epidemiológico y económico para la implementación de una decisión racional y eficiente. proceso de fabricación.(AU)

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BACKGROUND & OBJECTIVES: Dengue is one of the most important arboviruses and public health problem associated with increasingly large outbreaks, especially in tropical countries such as Brazil. The state of Minas Gerais, in particular, has had high numbers of cases of this infection in recent years. METHODS: Our study evaluated the epidemiological impact of dengue fever in the state of Minas Gerais from the National Health System (Sistema Único de Saúde, SUS) perspective between 2000 to 2015 using the Brazilian Notifiable Diseases Information System (SINAN, notification cases) and Hospital Information System (SIH)/SUS (hospitalization registers) databases. RESULTS: The SUS database recorded 34,996 reports of dengue (International Classification of Diseases [ICD]: A90) as well as 1984 verified cases of severe dengue (ICD-A91). These hospitalizations for dengue and cases of severe dengue generally affected individuals aged 15-24 (17.74%) and 5-14 (20.86%) years, respectively. The epidemiological burden of dengue was substantial in Minas Gerais state, with the highest number of notifications nationally in 2013. INTERPRETATION & CONCLUSION: From retrospective data associated with dengue records, our study sought to better highlight the locations with the largest number of dengue cases in the Minas Gerais state, and contribute to direct educational and surveillance actions of these regions applied to this infection.

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