RESUMEN

Two deoxy-analogues of the anticancer/antiviral agent pancratistatin containing functionality complementary to the minimum structural pharmacophore were synthesized and subjected to anticancer screening. One of the analogues exhibited selective inhibition of certain tumor cell lines but was significantly less potent than the natural products. The minimum structural pharmacophore has now been refined from eight to three possible structures.

Asunto(s)

Alcaloides de Amaryllidaceae , Antineoplásicos Fitogénicos/síntesis química , Isoquinolinas/farmacología , Animales , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , División Celular/efectos de los fármacos , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Concentración 50 Inhibidora , Isoquinolinas/síntesis química , Isoquinolinas/química , Ratones , Modelos Moleculares , Relación Estructura-Actividad , Células Tumorales Cultivadas/efectos de los fármacos