RESUMEN
Hypertrophic cardiomyopathy is the most common genetic heart disease. It is caused by a variety of mutations in genes encoding sarcomeric proteins. Clinical presentation is heterogeneous just as the clinical course, ranging from asymptomatic forms to sudden cardiac death in the young. The latter is an unpredictable, fortunately rather uncommon, complication with no reliable preventive treatment. The complexity lies in the identification of high risk patients who could benefit from an implantable cardioverter-defibrillator in primary prevention. Symptomatic patients presenting left ventricular outflow tract obstruction despite optimal medical treatment may undergo surgical septal myectomy or percutaneous alcohol septal ablation.
Asunto(s)
Cardiomiopatía Hipertrófica/terapia , Muerte Súbita Cardíaca/etiología , Desfibriladores Implantables , Técnicas de Ablación , Cardiomiopatía Hipertrófica/genética , Cardiomiopatía Hipertrófica/fisiopatología , Tabiques Cardíacos/cirugía , Humanos , Mutación , Prevención Primaria/métodos , Factores de Riesgo , Obstrucción del Flujo Ventricular Externo/etiología , Obstrucción del Flujo Ventricular Externo/terapiaRESUMEN
Delivery of cells into tubular tissue constructs with large diameters poses significant spatial and temporal challenges. This study describes preliminary findings for a novel process for rapid and uniform seeding of cells onto the luminal surface of large tubular constructs. Fibroblasts, tagged with superparamagnetic iron oxide nanoparticles (SPION), were directed onto the luminal surface of tubular constructs by a magnetic field generated by a k4-type Halbach cylinder device. The spatial distribution of attached cells, as measured by the mean number of cells, was compared with a conventional, dynamic, rotational cell-delivery technique. Cell loading onto the constructs was measured by microscopy and magnetic resonance imaging. The different seeding techniques employed had a significant effect on the spatial distribution of the cells (p < 0.0001). The number of attached cells at defined positions within the same construct was significantly different for the dynamic rotation technique (p < 0.05). In contrast, no significant differences in the number of cells attached to the luminal surface were found between the defined positions on the construct loaded with the Halbach cylinder. The technique described overcomes limitations associated with existing cell-delivery techniques and is amenable to a variety of tubular organs where rapid loading and uniform distribution of cells for therapeutic applications are required.
Asunto(s)
Trasplante de Células/métodos , Compuestos Férricos/uso terapéutico , Magnetismo , Nanopartículas de Magnetita/uso terapéutico , Ingeniería de Tejidos/métodos , Análisis de Varianza , Animales , Técnicas de Cultivo de Célula , Línea Celular , Supervivencia Celular , Compuestos Férricos/química , Nanopartículas de Magnetita/química , Ratones , Microscopía Electrónica de TransmisiónAsunto(s)
Fístula Arteriovenosa/etiología , Biopsia/efectos adversos , Vasos Coronarios/patología , Insuficiencia Cardíaca/cirugía , Trasplante de Corazón/patología , Miocardio/patología , Fístula Arteriovenosa/diagnóstico , Angiografía Coronaria , Diagnóstico Diferencial , Humanos , Masculino , Persona de Mediana EdadAsunto(s)
Estimulación Cardíaca Artificial/efectos adversos , Insuficiencia Cardíaca Sistólica , Síndrome del Seno Enfermo/terapia , Disfunción Ventricular Izquierda , Anciano , Ecocardiografía Tridimensional , Insuficiencia Cardíaca Sistólica/diagnóstico por imagen , Insuficiencia Cardíaca Sistólica/etiología , Humanos , Masculino , Disfunción Ventricular Izquierda/diagnóstico por imagen , Disfunción Ventricular Izquierda/etiologíaRESUMEN
Recanalization of chronic total occlusion remains a challenge for the interventional cardiologist and accounts for 10-20% of all angioplasty procedures in high-volume catheterization laboratories. During the last few years, development in guidewires and devices as well as the emergence of new techniques from japanese centers resulted in a higher success rates in experienced operator's hands. The impact of drug eluting stents on restenosis has improved longterm outcome after chronic total occlusion successfull recanalization. This procedure requires time, patience from the operator and does also expose the patient to increased radiation and contrast administrations. In symptomatic patients, when recanalization is successful, the clinical outcome and the event free survival are improved.
Asunto(s)
Arteriopatías Oclusivas/terapia , Angioplastia de Balón , Cateterismo Cardíaco , Enfermedad Crónica , HumanosRESUMEN
The tracking control of a disk rolling without slipping on the horizontal (X, Y)-plane is considered. The motion of the disk can be controlled via a tilting torque and a pedaling torque. The concept of path controllability of the disk is introduced and then used to calculate control laws such that the disk tracks a given path in the (X, Y)-plane.