RESUMEN

A set of substituted sulfadiazine compounds was prepared as cytotoxic and antitumor agents by using 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (1) as the starting material. Compound 1 was reacted with different reagents to give the corresponding sulfadiazines 2-18 and hydrozaones 19a-h which were evaluated for their in vitro cytotoxicity versus four cancer cell lines. Compounds 3, 5, 19d and 19h were active against the tested cancer cells.

Asunto(s)

Antineoplásicos/farmacología , Sulfadiazina/análogos & derivados , Sulfadiazina/farmacología , Animales , Antineoplásicos/síntesis química , Compuestos Azo/síntesis química , Compuestos Azo/farmacología , Línea Celular Tumoral , Chlorocebus aethiops , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Oxadiazoles/síntesis química , Oxadiazoles/farmacología , Piridinas/síntesis química , Piridinas/farmacología , Pirimidinas/síntesis química , Pirimidinas/farmacología , Células Vero