Some Studies in Sulfadiazine Incorporating Pyridine, Pyrimidine, Oxadiazole, and Azo Moieties Endowed with Pharmaceutical Potency.
Acta Chim Slov
; 67(1): 167-178, 2020 Mar.
Article
en En
| MEDLINE
| ID: mdl-33558911
A set of substituted sulfadiazine compounds was prepared as cytotoxic and antitumor agents by using 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (1) as the starting material. Compound 1 was reacted with different reagents to give the corresponding sulfadiazines 2-18 and hydrozaones 19a-h which were evaluated for their in vitro cytotoxicity versus four cancer cell lines. Compounds 3, 5, 19d and 19h were active against the tested cancer cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sulfadiazina
/
Antineoplásicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Acta Chim Slov
Año:
2020
Tipo del documento:
Article
Pais de publicación:
Eslovenia