RESUMEN
The antihypertensive effect of daily doses of three beta-adrenoblockers (Bisoprolol, 10 mg once a day, propranolol, 80 mg twice a day, and methoprolol, 100 mg twice a day), and placebo was examined in 14 patients with persistent mild and moderate hypertension during a double blind cross-over study by using 24-hour monitoring of blood pressure and its routine measurements. The latter made by a mercury sphygmomanometer indicated that the antihypertensive and negative chronotropic effect of Bisoprolol in a dose of 10 mg remained 24 hours after its administration and it did not significantly differ from that of the two other agents given in the above doses. The application of 24-hour blood pressure monitoring allows a more pronounced antihypertensive effect of bisoprolol to be revealed during 24 hours than that displayed by the two agents. Bisoprolol is an effective and safe antihypertensive agent.
Asunto(s)
Bisoprolol/uso terapéutico , Hipertensión/tratamiento farmacológico , Metoprolol/uso terapéutico , Propranolol/uso terapéutico , Adulto , Anciano , Análisis de Varianza , Presión Sanguínea/efectos de los fármacos , Preparaciones de Acción Retardada , Humanos , Hipertensión/fisiopatología , Masculino , Persona de Mediana Edad , Placebos , Factores de TiempoRESUMEN
The new original Russian drug proxodolol having alpha- and beta-adrenoblocking activities in a ratio of 1:100 was examined at Stages I and II of clinical trials. The drug was given to 29 male patients aged 30-63 years who suffered from Stages I and II persistent hypertensive disease with a baseline diastolic blood pressure of >95 mm Hg. Proxodolol as 10- and 40-mg tablets was demonstrated to be an effective antihypertensive agent, its antihypertensive effects being revealed in acute and chronic uses. The drug was well tolerated by the patients, causing no significant adverse reactions. Further comprehensive comparative controlled studies of proxodolol including larger patient groups will define the contribution of the drug in long-term antihypertensive prophylaxis.