[The antihypertensive effect of the new cardioselective prolonged-action beta-adrenoblocker bisoprolol compared with propranolol, metoprolol and placebo]. / Antigipertenzivnyi éffekt novogo kardioselektivnogo beta-adrenoblokatora prolongirovannogo deistviia bisoprolola v sravnenii s propranololom, metoprololom i platsebo.
Eksp Klin Farmakol
; 58(2): 32-4, 1995.
Article
en Ru
| MEDLINE
| ID: mdl-7773086
The antihypertensive effect of daily doses of three beta-adrenoblockers (Bisoprolol, 10 mg once a day, propranolol, 80 mg twice a day, and methoprolol, 100 mg twice a day), and placebo was examined in 14 patients with persistent mild and moderate hypertension during a double blind cross-over study by using 24-hour monitoring of blood pressure and its routine measurements. The latter made by a mercury sphygmomanometer indicated that the antihypertensive and negative chronotropic effect of Bisoprolol in a dose of 10 mg remained 24 hours after its administration and it did not significantly differ from that of the two other agents given in the above doses. The application of 24-hour blood pressure monitoring allows a more pronounced antihypertensive effect of bisoprolol to be revealed during 24 hours than that displayed by the two agents. Bisoprolol is an effective and safe antihypertensive agent.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Propranolol
/
Bisoprolol
/
Hipertensión
/
Metoprolol
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Asunto de la revista:
FARMACOLOGIA
Año:
1995
Tipo del documento:
Article
Pais de publicación:
Rusia