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PURPOSE: To evaluate the performance of fully crystallized zirconia-reinforced lithium silicate (Celtra Duo, ZLS-CD), partially crystallized zirconia-reinforced lithium silicate (Vita Suprinity, ZLS-VS), and partially sintered lithium disilicate-based (IPS e.max CAD, LD) glass-ceramics submitted to polishing, glazing, or no surface treatment after aging. MATERIAL AND METHODS: Samples of each glass-ceramic material were subjected to polishing with rubber cups (POL), glazing (GL), or no treatment (control: unpolished) and afterward aged with 18,000 thermal cycles (5.C to 55.C). The average roughness, 2D and 3D morphology, contact angle, multispecies biofilm formation (Streptococcus mutans and Candida albicans), and mechanical strength were evaluated with atomic force microscopy (AFM, n = 5), sessile-drop goniometry (n = 5), spectrophotometry (n = 5), and the flexural strength test (n = 10), respectively. Data were analyzed using two-way ANOVA and Tukey test (α = 5%). RESULTS: POL produced lower surface roughness than GL, and ZLS-CD presented higher roughness than LD (P < .05). Surfaces without polishing displayed higher roughness than the POL group (P < .001), greater contact angle (P < .001), and significant morphologic changes, regardless of the glass-ceramic material. Irrespective of the treatment, the contact angle was higher in the ZLS-CD group, and regardless of the material, there was higher biofilm formation and lower flexural strength of the unpolished compared to the POL or GL ceramics. CONCLUSIONS: POL promoted lower roughness and minor morphologic surface alterations, but biofilm formation and flexural strength were similar to the GL group. In general, ZLS-CD and ZLS-VS showed more similar behavior than LD, which makes ZLS glass-ceramic a good option for indirect restorations.

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(1) Background: To investigate the grouping of obesity and insulin resistance with caries and periodontitis from a syndemic perspective through pathways of socioeconomic inequalities, smoking, alcohol, and high sugar consumption in adolescence. (2) Methods: The population-based RPS Cohort study, São Luís, Brazil, in ages 18-19 years (n = 2515) was used. The outcomes were the grouping of pbesity and Insulin Resistance Phenotype (latent variable formed by Triglycerides/HDL ratio, TyG index, and VLDL) and the Chronic Oral Disease Burden (latent variable comprising caries, bleeding on probing, probing depth ≥ 4 mm, clinical attachment level ≥ 3 mm, and visible plaque index ≥ 15%). Socioeconomic Inequalities influencing the Behavioral Risk Factors (latent variable formed by added sugar, smoking, and alcohol) were analyzed using structural equation modeling. (3) Results: Socioeconomic Inequalities were associated with the Chronic Oral Disease Burden [Standardized Coefficient (SC) = 0.222, p < 0.001]. Behavioral Risk Factors were associated with increased Chronic Oral Disease Burden (SC = 0.103; p = 0.013). Obesity was associated with the Insulin Resistance Phenotype (SC = 0.072; p < 0.001) and the Chronic Oral Disease Burden (SC = 0.066; p = 0.005). The Insulin Resistance Phenotype and the Chronic Oral Disease Burden were associated (SC = 0.053; p = 0.032). (4) Conclusion: The grouping of obesity and early events of diabetes with caries and periodontitis call for a syndemic approach in adolescence.

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OBJECTIVE: To analyze the association between birth weight and bone mineral density (BMD) in adolescence. METHODS: A birth cohort study in São Luís, Maranhão, using data from two moments: at birth and at 18-19 years. Exposure was the birth weight in grams, continuously analyzed. The outcome was BMD, using the Z-score index (whole body) measured by double X-ray densitometry (Dexa). A theoretical model was constructed in acyclic graphs to identify the minimum set of adjustment variables - household income, the mother knowing how to read and write at the time of birth, prenatal care, tobacco use during pregnancy, and parity - to evaluate the association between birth weight and bone mineral density in adolescence. Multiple linear regression was used in Stata 14.0 software. A 5% significance level was adopted. RESULTS: From 2,112 adolescents, 8.2% had low birth weight and 2.8% had a low BMD for their age. The mean full-body Z-score was 0.19 (± 1.00). The highest birth weight was directly and linearly associated with BMD values in adolescence (Coef.: 0.10; 95%CI: 0.02-0.18), even after adjustment for the variables household income (Coef.: -0.33; 95%CI: -0.66-0.33) and the mother knowing how to read and write (Coef.: 0.23%; 95%CI: 0.03-0.43). CONCLUSION: Although after adjusting the variables the association attenuated, birth weight positively and linearly relates to BMD in adolescence.

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ABSTRACT OBJECTIVE To analyze the association between birth weight and bone mineral density (BMD) in adolescence. METHODS A birth cohort study in São Luís, Maranhão, using data from two moments: at birth and at 18-19 years. Exposure was the birth weight in grams, continuously analyzed. The outcome was BMD, using the Z-score index (whole body) measured by double X-ray densitometry (Dexa). A theoretical model was constructed in acyclic graphs to identify the minimum set of adjustment variables - household income, the mother knowing how to read and write at the time of birth, prenatal care, tobacco use during pregnancy, and parity — to evaluate the association between birth weight and bone mineral density in adolescence. Multiple linear regression was used in Stata 14.0 software. A 5% significance level was adopted. RESULTS From 2,112 adolescents, 8.2% had low birth weight and 2.8% had a low BMD for their age. The mean full-body Z-score was 0.19 (± 1.00). The highest birth weight was directly and linearly associated with BMD values in adolescence (Coef.: 0.10; 95%CI: 0.02-0.18), even after adjustment for the variables household income (Coef.: -0.33; 95%CI: -0.66-0.33) and the mother knowing how to read and write (Coef.: 0.23%; 95%CI: 0.03-0.43). CONCLUSION Although after adjusting the variables the association attenuated, birth weight positively and linearly relates to BMD in adolescence.

RESUMO OBJETIVO Analisar a associação entre o peso ao nascer e a densidade mineral óssea (DMO) na adolescência. MÉTODOS Estudo de coorte de nascimentos em São Luís, Maranhão, utilizando dados de dois momentos: ao nascimento e aos 18-19 anos. A exposição foi o peso ao nascer em gramas, analisado de forma contínua. O desfecho foi a DMO, utilizando o índice Z-escore (corpo inteiro) medido pela densitometria por dupla emissão de raios X (DEXA). Foi construído modelo teórico em gráficos acíclicos direcionados para identificar o conjunto mínimo de variáveis de ajuste - renda familiar, a mãe saber ler e escrever à época do nascimento, realização de pré-natal, tabagismo durante a gestação e paridade - para avaliar a associação entre o peso ao nascer e a densidade mineral óssea na adolescência. Utilizou-se regressão linear múltipla no software Stata 14.0. O nível de significância adotado foi de 5%. RESULTADOS Dos 2.112 adolescentes, 8,2% apresentaram baixo peso ao nascer e 2,8% apresentaram DMO considerada baixa para a idade. O Z-escore médio de corpo inteiro foi de 0,19 (± 1,00). O maior peso ao nascer foi associado de forma linear e direta aos valores de DMO na adolescência (Coef.: 0,10; IC95% 0,02-0,18), mesmo após ajuste para as variáveis renda familiar (Coef.: -0,33; IC95% -0,66-0,33) e a mãe saber ler e escrever (Coef.: 0,23; IC95% 0,03-0,43). CONCLUSÕES Apesar de a associação ter sido atenuada após ajuste das variáveis, o peso ao nascer está associado de forma positiva e linear à DMO na adolescência.

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We hypothesize that early events of diabetes and cardiovascular disease continuums would be ongoing and associated in adolescents. We investigated the association between the Insulin Resistance Phenotype and the Vascular Risk Phenotype at the end of the second decade of life and indirect pathways from social vulnerability, alcohol consumption, and body fat mass. It is a population-based study in the RPS cohort of 18-19 years (n = 2,515), São Luís, Brazil. The theoretical model analyzed the association between Insulin Resistance Phenotype and Vascular Risk Phenotype by sex, using structural equation modeling (SEM). The Insulin Resistance Phenotype was a latent variable deduced from the correlations of Triglyceride to HDL ratio, Triglyceride Glycemic index, and VLDL; the Vascular Risk Phenotype was deduced from Systolic Blood Pressure, Diastolic Blood Pressure, and Pulse Wave Velocity. The Insulin Resistance Phenotype was directly associated with the Vascular Risk Phenotype in males (standardized coefficient SC = 0.183; p < 0.001) and females (SC = 0.152; p < 0.001). The Insulin Resistance Phenotype was an indirect pathway in the association of alcohol consumption and higher values of fat mass index with the Vascular Risk Phenotype. VLDL presented the highest factor loading, appearing as a marker of insulin resistance linked to cardiovascular risk in young people. Lower values of socioeconomic status, harmful use of alcohol, and high body fat values were also associated with higher values of the two phenotypes. The association of the Insulin Resistance Phenotype with the Vascular Risk Phenotype suggests common pathophysiological mechanisms present in early events in the continuums of diabetes and cardiovascular disease in adolescence.

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Abstract Objectives: to investigate the association between prepregnancy body mass index (BMI) and newborns' (NB) BMI. Methods: cohort study with 1,365 pregnant women and their newborns from the BRISA survey (Brazilian Ribeirão Preto and São Luís Birth Cohort Studies) in São Luís-MA. Prepregnancy BMI was self-reported, and newborns' BMI was estimated using the weight and length measured at birth. A directed acyclic graph (DAG) was developed to identify the adjustment variables. The association between the prepregnancy BMI and newborns' BMI were analyzed using multiple linear and Poisson regression with robust variance estimation. Results: NBs had 13.4±1.7kg/m2 average BMI at birth. In the linear analysis, we observed that as the prepregnancy BMI increases, the NBs BMI also increases (ß=0.07; CI95%=0.05-0.09;p<0.001). Newborns of mothers with prepregnancy overweight were 3.58 times more likely to be overweight. Conclusion: prepregnancy BMI can affect newborn's BMI early. Thus, women planning to become pregnant should consider conducting nutritional planning to maintain or obtain a healthy weight to minimize the risk of overweight for the newborn.

Resumo Objetivos: investigar a associação entre o Índice de Massa Corporal (IMC) pré-gestacional e o IMC do recém-nascido (RN). Métodos: estudo de coorte, com 1365 gestantes e seus RN, participantes da pesquisa BRISA (Brazilian Ribeirão Preto and São Luís Birth Cohort Studies) em São Luís-MA. O IMC pré-gestacional foi autorreferido e o IMC do RN foi calculado por meio do peso e comprimento aferidos na ocasião do nascimento. Foi elaborado um Gráfico Acíclico Direcionado (DAG)para identificaras variáveis de ajuste. A associação entre o IMC pré-gestacional e IMC do RN foram analisados por regressão linear múltipla e regressão de Poisson com estimativa robusta da variância. Resultados: os RN tiveram IMC ao nascer médio de 13,4 ± 1,7 kg/m2. Na análise linear, foi observada que à medida que o IMC pré-gestacional aumenta, o IMC do RN também aumenta (ß= 0,07; IC95%= 0,05 - 0,09; p<0.001). RN de mães com excesso de peso pré-gestacional tiveram risco 3,58 vezes maior de terem excesso de peso. Conclusão: o IMC pré-gestacional pode afetar precocemente o IMC do RN. Dessa forma, recomenda-se que mulheres que planejem engravidar considerem realizar um planejamento nutricional para a manutenção ou obtenção de um peso saudável, a fim de minimizar o risco de excesso de peso para o RN.

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Este estudo teve como objetivo investigar as relações entre psicose e cuidados com o corpo. Adotou-se o método do relato de experiência, a partir do trabalho em um Centro de Atenção Psicossocial (CAPS). Conteúdos delirantes podem se colocar como impasses para a promoção da saúde. Há um importante índice de comorbidades clínicas em pessoas com diagnóstico de transtornos mentais crônicos, em decorrência de fatores como tabagismo, dieta precária, sedentarismo e efeitos colaterais de medicamentos. A Saúde Mental é uma clínica de sujeitos, de singularidades que precisam existir e conviver num coletivo, o que exige uma criatividade e uma sensibilidade que não cabe nos protocolos. É preciso construir um cuidado possível, coerente com os recursos que cada sujeito encontra para estar no mundo.

Resumos The purpose of this study was to investigate the relation between psychosis and body care. The experience report method was adopted, based on a work performed in a Psychosocial Care Center (CAPS). Delusional contents may hamper health promotion. There is an important rate of clinical comorbidities in people diagnosed with chronic mental disorders, due to factors such as smoking, poor diet, sedentary lifestyle, and medication side effects. Mental Health is a clinic of subjects, of singularities that need to exist and coexist in a collective, which requires creativity and sensitivity that does not fit into protocols. We need to build a possible care, consistent with the means that enable each subject to be in the world.

Le but de cette étude était d'étudier la relation entre la psychose et les soins corporels. La méthode du rapport d'expérience a été adoptée, basée sur le travail dans un Centre d'Aide Psychosociale (CAPS). Les contenus délirants peuvent constituer des impasses pour la promotion de la santé. Un taux important de comor-bidités cliniques se manifeste chez les personnes diagnostiquées avec des troubles mentaux chroniques en raison de facteurs tels que le tabagisme, une mauvaise alimentation, un mode de vie sédentaire et les effets secondaires des médicaments. La Santé Mentale est une clinique de sujets, de singularités qui ont besoin d'exister et de vivre ensemble dans un collectif, ce qui demande de la créativité et de la sensibilité qui ne rentrent pas dans les protocoles. Il faut construire un soin possible, compatible avec les ressources que chaque sujet trouve pour se situer dans le monde.

El objetivo de este estudio fue investigar la relación entre la psicosis y el cuidado corporal. Se adoptó el método del informe de experiencia, a partir del trabajo realizado en un Centro de Atención Psicosocial (CAPS). El contenido delirante puede representar un obstáculo para la promoción de la salud. Existe una importante tasa de comorbilidades clínicas en personas diagnosticadas con trastornos mentales crónicos, debido a factores como el tabaquismo, la mala alimentación, el sedentarismo y los efectos secundarios de los medicamentos. La Salud Mental es una clínica de sujetos, de singularidades que necesitan existir y convivir en un colectivo, esto requiere una creatividad y una sensibilidad que no encajan en los protocolos. Es necesario construir un cuidado posible, coherente con los recursos que cada sujeto encuentra para vivir en el mundo.

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Noncommunicable diseases (NCDs) and mental disorders cooccur in adulthood, which is why their determinants and common risk factors should be addressed at an early age. Therefore, we estimated the association of the major risk factors for NCDs with depression and suicide risk by structural equation modeling considering pathways triggered by social vulnerability or mediated by obesity. This population-based study included 2,515 Brazilian adolescents. The following exposures were the major risk factors for NCDs: substance use behaviors (variable deduced from alcohol, tobacco, and drug use), physical inactivity, and components of unhealthy eating markers (added sugar and saturated fat). Obesity was assessed using the fat mass index. The outcomes were depression and suicide risk. Depression was associated with substance use behaviors (SC = 0.304; p < 0.001), added sugar (SC = 0.094; p = 0.005), and females (SC = 0.310; p < 0.001). Suicide risk was also associated with substance use behaviors (SC = 0.356; p < 0.001), added sugar (SC = 0.100; p = 0.012), and females (SC = 0.207; p < 0.001). In adolescents, these associations may help explain the cluster of NCDs and mental disorders in adulthood.

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This is a cross-sectional study conducted with pregnant women who underwent prenatal care at basic health units in São Luís City, Maranhão State, Brazil. The authors used a semistructured questionnaire to assess the socioeconomic, demographic, and clinical characteristics of pregnant women as well as the Edinburgh Scale to investigate depressive symptoms. In order to assess the association between the explanatory variable and the outcome variable, Poisson logistic regression was performed with statistical significance at p < 0.05. A total of 205 women were interviewed, most aged between 18 and 29 years (66.83%). Of this total, 74.63% had not planned their pregnancy and 26.67% had depressive symptoms. The variables unplanned pregnancy (PR = 1.41; CI = 0.99−2.00; p = 0.05) and not undergoing psychological counseling (PR = 1.42; CI = 0.51−0.83; p ≤ 0.01) correlated with depressive symptoms during pregnancy. It is thus possible to link the variables unplanned pregnancy (p > 0.05) and not undergoing psychological counseling (p = 0.001) to depression. Therefore, it is important to monitor the mental health of pregnant women, especially in situations of vulnerability.

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Noncommunicable diseases (NCDs) and mental disorders cooccur in adulthood, which is why their determinants and common risk factors should be addressed at an early age. Therefore, we estimated the association of the major risk factors for NCDs with depression and suicide risk by structural equation modeling considering pathways triggered by social vulnerability or mediated by obesity. This population-based study included 2,515 Brazilian adolescents. The following exposures were the major risk factors for NCDs: substance use behaviors (variable deduced from alcohol, tobacco, and drug use), physical inactivity, and components of unhealthy eating markers (added sugar and saturated fat). Obesity was assessed using the fat mass index. The outcomes were depression and suicide risk. Depression was associated with substance use behaviors (SC = 0.304; p < 0.001), added sugar (SC = 0.094; p = 0.005), and females (SC = 0.310; p < 0.001). Suicide risk was also associated with substance use behaviors (SC = 0.356; p < 0.001), added sugar (SC = 0.100; p = 0.012), and females (SC = 0.207; p < 0.001). In adolescents, these associations may help explain the cluster of NCDs and mental disorders in adulthood.

As doenças não transmissíveis (DNT) e transtornos mentais podem ocorrer simultaneamente na vida adulta, razão pela qual seus determinantes e fatores de risco comuns devem ser abordados em idade precoce. Portanto, estimamos a associação entre os principais fatores de risco para DNT e a depressão e risco de suicídio através da modelagem de equações estruturais, considerando os caminhos desencadeados pela vulnerabilidade social ou mediados pela obesidade. Este estudo de base populacional incluiu 2.515 adolescentes brasileiros. As exposições foram os principais fatores de risco para DNT: comportamento de risco viciante (variável latente deduzida a partir do uso de álcool, tabaco e drogas), inatividade física e componentes da dieta não saudável (açúcar de adição e gordura saturada). A obesidade foi avaliada pelo índice de massa gorda. Os desfechos foram depressão e risco de suicídio. Comportamento de risco viciante (CP = 0,304; p < 0,001), açúcar de adição (CP = 0,094; p = 0,005) e sexo feminino (CP = 0,310; p < 0,001) estiveram associados à depressão. Comportamento de risco viciante (CP = 0,356; p < 0,001), açúcar de adição (CP = 0,100; p = 0,012) e sexo feminino (CP = 0,207; p < 0,001) também estiveram associados ao risco de suicídio. Comportamento de risco viciante e açúcar de adição estiveram associados à depressão e ao risco de suicídio em adolescentes, fato este que pode ajudar a explicar o agrupamento de DNT e transtornos mentais na vida adulta.

Las enfermedades no comunicables (ENTs) y los desórdenes mentales ocurren en la etapa adulta, un hecho que da impulso para dirigirse a sus determinantes y factores de riesgo comunes a una edad temprana. Por ello estimamos la asociación de los mayores factores de riesgo para ENTs con la depresión y riesgo de suicidio mediante un modelo de ecuación estructural, considerando trayectorias derivadas de la vulnerabilidad social o mediadas por la obesidad. Este estudio basado en población incluyó a 2.515 adolescentes brasileños. Las exposiciones fueron los mayores factores de riesgo para las ENTs: comportamiento en el uso de sustancias (variable latente deducida del alcohol, tabaco y consumo de drogas), inactividad física y componentes de marcadores de consumo de comida insana (azúcar añadido y grasas saturadas). La obesidad fue evaluada usando el índice de masa grasa. Los resultados fueron depresión y riesgo de suicidio. Los comportamientos en el uso de sustancias (CE = 0,304; p < 0,001), azúcar añadido (CE = 0,094; p = 0,005), y sexo femenino (CE = 0,310; p < 0,001) estuvieron asociados con depresión. Comportamientos en el consumo de sustancias (CE = 0,356; p < 0,001) y azúcar añadido (CE = 0,100; p = 0,012) y el sexo femenino (CE = 0,207; p < 0,001) estuvieron también asociados con el riesgo de suicidio. Los comportamientos en el consumo de sustancias y de azúcar añadido, estuvieron asociados con la depresión y el riesgo de suicidio en adolescentes, un hecho que puede ayudar a explicar la concentración de ENTs y desórdenes mentales en la etapa adulta.

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OBJECTIVES: The essential oil (EO) extracted from Cinnamomum verum leaves has been used as an antimicrobial agent for centuries. But its antifungal and antibiofilm efficacy is still not clearly studied. The objective of this research was to evaluate the in vitro antifungal and antibiofilm efficacy of C. verum leaf EO against C. albicans, C. tropicalis, and C. dubliniensis and the toxicity of EO using an in vitro model. MATERIALS AND METHODS: The effect of EO vapor was evaluated using a microatmosphere technique. CLSI microdilution assay was employed in determining the Minimum Inhibitory (MIC) and Fungicidal Concentrations (MFC). Killing time was determined using a standard protocol. The effect of EO on established biofilms was quantified and visualized using XTT and Scanning Electron Microscopy (SEM), respectively. Post-exposure intracellular changes were visualized using Transmission Electron Microscopy (TEM). The toxicological assessment was carried out with the Human Keratinocyte cell line. The chemical composition of EO was evaluated using Gas Chromatography-Mass Spectrometry (GC-MS). RESULTS: All test strains were susceptible to cinnamon oil vapor. EO exhibited MIC value 1.0 mg/ml and MFC value 2.0 mg/ml against test strains. The killing time of cinnamon oil was 6 hr. Minimum Biofilm Inhibitory Concentration (MBIC50) for established biofilms was <0.2 mg/ml for all test strains. SEM images exhibited cell wall damages, cellular shrinkages, and decreased hyphal formation of Candida. TEM indicated intracellular vacuolation, granulation, and cell wall damages. Cinnamon leaf oil caused no inhibition of HaCaT cells at any concentration tested. Eugenol was the abundant compound in cinnamon oil. CONCLUSION: C. verum EO is a potential alternative anti-Candida agent with minimal toxicity on the human host.

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This study aimed to determine the antifungal and antibiofilm activities of Agelas dispar on biofilm-producing Candida species. The methanolic extract of A. dispar was obtained and the fraction Ag2 showed inhibitory activity for all 13 Candida strains tested, in concentrations ranging from 2.5 to 0.15625 mg/mL. Antifungal activity of fungicidal nature was seen between 5.0 and 0.3125 mg/mL of extract against the strains. All the strains were classified as biofilm producers. The methanolic extract Ag2 was tested at concentrations of 2.5 and 1.25 mg/mL for antibiofilm activity against the biofilm formation and maturation in all the strains of the genus Candida. Treated and untreated biofilm samples were selected for visualization using scanning electron microscopy (SEM). SEM allowed the visualization of the quantitative decrease in the microbial community, alterations of structural morphology, and destruction of both the formation and maturation of biofilms, at the cellular level. The mechanism of action of this fraction is suggested to be at the plasma membrane and/or cell wall alteration level. Therefore, the use of the methanolic extract of A. dispar may be a promising antifungal and antibiofilm therapeutic strategy against different species of the genus Candida.

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Abstract Background: The use of pequi by-product as animal feed is an appealing alternative to reduce overall production costs. However, little is known regarding its effects on animal performance as well as the ideal inclusion level in the diet. Objective: To evaluate performance, intake, and digestibility of confined lambs receiving diets containing different levels of pequi by- product as a partial substitute for corn silage. Methods: The experiment was conducted in Curvelo, Brazil, using twenty-five crossbred Santa Inês male lambs (17.83 ± 1.73 kg) aged six months for 92 days. Increasing levels of pequi by-product (0, 6, 12, 18, and 24%) replacing corn silage were evaluated in a completely randomized design. Analysis of variance and regression were performed, with 5% significance level. Results: Inclusion of pequi by-product did not influence (p>0.05) average daily gain, total weight gain, or feed conversion ratio. No effect (p>0.05) was also observed on intake of dry matter, organic matter, ether extract, crude protein, neutral detergent fiber, total carbohydrates, and total digestible nutrients. However, a linear decrease was observed (p<0.05) in the apparent digestibility of dry matter, organic matter, ether extract, crude protein, neutral detergent fiber, total carbohydrates, and total digestible nutrients with increasing inclusion of pequi by-product. Conclusion: Pequi by-product is a potential substitute for corn silage in lamb diets because it does not influence animal performance and feed intake. However, digestibility decreases with increasing dietary inclusion levels of pequi by-product.

Resumen Antecedentes: la inclusion de subproductos de pequi en alimentación animal es una estrategia atractiva para reducir los costos de producción. Sin embargo, todavía se sabe poco sobre el efecto de este subproducto en el rendimiento de los animales, así como su nivel ideal de inclusión en la dieta. Objetivo: evaluar el rendimiento, consumo y digestibilidad en corderos confinados recibiendo dietas con subproducto de pequi en reemplazo parcial del ensilado de maíz. Métodos: el experimento se realizó en Curvelo, Brasil, utilizando 25 corderos machos cruzados de raza Santa Inês (17,83 ± 1,73 kg) y 6 meses de edad, durante 92 días. Se evaluaron niveles crecientes del subproducto de pequi (0, 6, 12, 18 y 24%) para sustituir el ensilado de maíz siguiendo un diseño completamente aleatorio. Los análisis de varianza y regresión se llevaron a cabo usando un nivel de significancia del 5%. Resultados: la inclusión del subproducto de pequi no influyó (p>0,05) en la ganancia de peso diaria, ganancia de peso total, ni conversión alimenticia. No se observó efecto (p>0,05) en la ingesta de materia seca, materia orgánica, extracto etéreo, proteína bruta, fibra detergente neutra, carbohidratos totales y nutrientes digestibles totales. Sin embargo, se observó una reducción lineal (p<0,05) en la digestibilidad aparente de materia seca, materia orgánica, extracto etéreo, proteína bruta, fibra detergente neutra, carbohidratos totales y nutrientes digestibles totales con el aumento del nivel de inclusión del subproducto. Conclusión: el subproducto de pequi puede utilizarse como sustituto parcial del ensilado de maíz, ya que no afecta la ganancia de peso ni la ingesta de nutrientes. Sin embargo, la digestibilidad disminuye al aumentar el nivel de inclusión del subproducto en la dieta.

Resumo Antecedentes: o uso de subprodutos do pequi na alimentação animal é uma estratégia atraente que busca a redução dos custos de produção. Entretanto, pouco ainda se sabe sobre o efeito desse subproduto no desempenho animal assim como qual seria o nível ideal da sua inclusão na dieta. Objetivo: avaliar o desempenho, consumo e digestibilidade em cordeiros confinados recebendo dietas contendo subproduto de pequi em substituição à silagem de milho. Métodos: o experimento foi conduzido em Curvelo, Brasil, utilizando 25 cordeiros machos cruzados da raça Santa Inês (17,83 ± 1,73 kg) com 6 meses de idade durante 92 dias. Níveis crescentes do subproduto de pequi (0, 6, 12, 18 e 24%) foram avaliados em substituição à silagem de milho em um delineamento inteiramente casualizado. A análise de variância e regressão foram conduzidas adotando 5% como nível de significância. Resultados: a inclusão do subproduto de pequi não influenciou (p>0,05) o ganho de peso médio diário, o ganho de peso total e a conversão alimentar. Também não foi observado efeito (p>0,05) no consumo de matéria seca, matéria orgânica, extrato etéreo, proteína bruta, fibra em detergente neutro, carboidratos totais e nutrientes digestíveis totais. Entretanto, foi observada redução linear (p<0,05) na digestibilidade aparente da matéria seca, matéria orgânica, extrato etéreo, proteína bruta, fibra em detergente neutro, carboidratos totais e nutrientes digestíveis totais com o aumento da inclusão do subproduto. Conclusão: o subproduto de pequi pode ser utilizado como substituto parcial à silagem de milho uma vez que não influenciou o desempenho animal ou o consumo de nutrientes. No entanto, a digestibilidade diminuiu com o aumento do nível de inclusão do subproduto na dieta.

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Objetivo: refletir sobre a necessidade de implantação da avaliação de desempenho dos profissionais de saúde do município de São Tomé-RN. Método: Trata-se de um ensaio reflexivo, de caráter descritivo e de abordagem qualitativa. Resultados: Tem-se a necessidade de sensibilizar a gestão, na perspectiva de implantar uma avaliação de desempenho, a partir de instrumentos, tendo em vista várias necessidades tais como: perfil profissional, assiduidade, comportamento profissional, capacitações de educação continuada, viabilizar desempenho eficaz do profissional, melhorar condições de trabalho e qualidade de vida no trabalho. Conclusão: Para concretizar a implantação de avaliação de desempenho é preciso que haja um bom planejamento; realizar diagnósticos na gestão com bases nos problemas levantados, constatar problemas não é o suficiente para provocar mudanças necessárias. Faz-se imperativo, portanto, empenhar-se na construção de estratégias que possam promover mudanças no cotidiano dos serviços de saúde que possam vir a contribuir para melhoria da gestão.(AU)

Objective: to reflect on the need to implement the performance evaluation of health professionals in the municipality of São Tomé-RN. Method: This is a reflective essay, with a descriptive character and a qualitative approach. Results: There is a need to sensitize management, with a view to implementing a performance evaluation, based on instruments, in view of various needs such as: professional profile, attendance, professional behavior, continuing education skills, enabling effective performance professional, improve working conditions and quality of life at work. Conclusion: In order to implement the performance evaluation, there must be good planning; making diagnoses in management based on the problems raised, finding problems is not enough to cause necessary changes. It is imperative, therefore, to commit to the construction of strategies that can promote changes in the daily life of health services that may contribute to improve management.(AU)

Objetivo: reflexionar sobre la necesidad de implementar la evaluación del desempeño de los profesionales de la salud en el municipio de São Tomé-RN. Método: Se trata de un ensayo reflexivo, con carácter descriptivo y enfoque cualitativo. Resultados: Existe la necesidad de sensibilizar a la gestión, con miras a implementar una evaluación de desempeño, basada en instrumentos, ante diversas necesidades tales como: perfil profesional, asistencia, comportamiento profesional, capacidades de educación continua, posibilitando un desempeño efectivo profesional, mejorar las condiciones laborales y la calidad de vida en el trabajo. Conclusión: Para implementar la evaluación de desempeño, debe haber una buena planificación; haciendo diagnósticos en la gestión basados en los problemas planteados, encontrar problemas no es suficiente para provocar los cambios necesarios. Por tanto, es imperativo apostar por la construcción de estrategias que puedan promover cambios en la vida diaria de los servicios de salud que contribuyan a mejorar la gestión.(AU)

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BACKGROUND: Growth of uterus, enlargement of breasts and weight gain result from the development and growth of the fetus during pregnancy. The posture and the displacement of the center of gravity change. OBJECTIVE: Correlate baropodometric variables with low back pain in pregnant women in the third trimester of pregnancy. METHODS: This is a cross-sectional analytical study conducted in São Luís (MA, Brazil). For data collection, we used a form containing sociodemographic and clinical data, Oswestry Disability Questionnaire for disability evaluation of the lumbar spine, Numerical Rating Scale to measure pain intensity, and baropodometric evaluation. RESULTS: Twenty-five pregnant women took part in the study. There was a significant and positive correlation (r = 0.404, p = 0.045) between functional disability and hindfoot pressure and a significant and negative correlation (r = -0.404, p = 0.045) between functional disability and plantar pressure in the forefoot of the right foot. In addition, there was a positive and significant correlation between the intensity of pain and the contact area on the left (r = 0.504, p = 0.010) and right (r = 0.509, p = 0.009) foot. CONCLUSION: There is a relation between disability and plantar pressure and between pain intensity and area of contact of feet in pregnant women.

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Phytomedicines are becoming more popular in treatment of infectious diseases worldwide. Cinnamomum verum essential oil (EO) has been used as a therapeutic alternative for various diseases. This study aimed to evaluate the antibacterial and antibiofilm activity of the C. verum leaf EO against Pseudomonas aeruginosa, Staphylococcus aureus and Klebsiella pneumoniae. Effect of EO vapor on planktonic cells was determined using microatmosphere technique. CLSI M7-A10 method was employed in Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) experiments. Effect of EO on established biofilms was quantified and visualized using XTT and Scanning Electron Microscope (SEM). In-vitro toxicity was evaluated using Human Keratinocytes (HaCaT). Chemical analysis of EO was done using Gas Chromatography- Mass Spectrometry (GC-MS). All tested strains were sensitive to cinnamon oil vapor. EO exhibited 0.5 and 1.0 mg/mL MIC and MBC against all test strains. Minimum Biofilm Inhibitory and Biofilm Eradication Concentrations (MBIC50 and MBEC) were 1.0 and 4.0 mg/mL. SEM indicated cellular shrinkages, cell wall damages, and decreased biofilm densities. Cinnamon oil didn't show any toxicity on HaCaT cell at any concentration tested. Eugenol was the most abundant compound in C. verum oil. C. verum EO shows an antibacterial and antibiofilm activity with minimal toxicity on host.

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Objetivo: descrever a situação epidemiológica de pessoas que foram vítimas de violência autoprovocada em um estado do nordeste brasileiro. Método: trata-se de estudo exploratório e descritivo, com abordagem quantitativa e dados retrospectivos, desenvolvido com dados obtidos do Sistema de Informação de Agravos de Notificação (SINAN). A população compreendeu todas as pessoas que foram atendidas e notificadas nos serviços próprios e conveniadas ao Sistema Único de Saúde entre 2015 e 2018. Resultados: Observou-se que a maior parte era do sexo feminino (65,47%), na faixa etária de 25 a 59 anos de idade (48,4%), heterossexual (43,8%), sem identificação da identidade de gênero (54,3%), raça/cor parda (51,37%), ensino fundamental incompleto (18,46%), zona urbana (90,33%) e solteiro (43,62%). Considerações finais: A violência autoprovocada é considerada importante problema de saúde pública no Brasil, sendo imperativo o desenvolvimento de ações educativas que visem à divulgação dos riscos, programas de prevenção e de suas complicações.(AU)

Objective: describes an epidemiological situation of people who were victims of self-harm in a northeastern Brazilian state. Method: this is an exploratory and descriptive study, with a quantitative approach and retrospective data, developed with data obtained from the Notifiable Diseases Information System (SINAN). The population comprised all the people who were attended and notified in the services themselves and affiliated to the Unified Health System between 2015 and 2018. Results: It was observed that most of them were female (65.47%), in the age group from 25 to 59 years old (48.4%), heterosexual (43.8%), without identification of gender identity (54.3%), race/ brown color (51.37%), incomplete elementary school (18.46 %), urban area (90.33%) and single (43.62%). Final considerations: Self-harm is considered an important public health problem in Brazil, and it is imperative to develop educational actions aimed at disseminating risks, prevention programs and their complications.(AU)

Objetivo: describir la situación epidemiológica de las personas víctimas de autolesiones en un estado del noreste de Brasil. Método: se trata de un estudio exploratorio y descriptivo, con enfoque cuantitativo y datos retrospectivos, desarrollado con datos obtenidos del Sistema de Información de Enfermedades Notificables (SINAN). La población comprendió a todas las personas que fueron atendidas y notificadas en sus propios servicios y afiliadas al Sistema Único de Salud entre 2015 y 2018. Resultados: Se observó que la mayoría eran mujeres (65,47%), en el grupo de edad de 25 a 59 años (48,4%), heterosexual (43,8%), sin identificación de identidad de género (54,3%), raza/ color marrón (51,37%), primaria incompleta (18, 46%), área urbana (90,33%) y soltera (43,62%). Consideraciones finales: La violencia autoinfligida es considerada un importante problema de salud pública en Brasil, y es imperativo desarrollar acciones educativas dirigidas a la difusión de riesgos, programas de prevención y sus complicaciones.(AU)

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Objetivo: descrever a situação epidemiológica de pessoas que foram vítimas de maus-tratos, negligência ou abandono em um estado do nordeste brasileiro. Método: Trata-se de estudo exploratório e descritivo, com abordagem quantitativa e dados retrospectivos, desenvolvido com dados obtidos do Sistema de Informação de Agravos de Notificação. Resultados: A população compreendeu pessoas atendidas e notificadas nos serviços próprios e conveniados ao Sistema Único de Saúde, por causas de maus-tratos, negligência ou abandono, entre 2015 e 2018. Observou-se que a maior parte era do sexo feminino (59,6%), na faixa etária de até 9 anos (56,4%) e residentes da zona urbana (79,1%). Quanto as pessoas que cometeram maus-tratos, negligência ou abandono, a maioria era do sexo feminino, não havia ingerido bebida alcóolica e a violência foi motivada por conflito geracional (20%). Conclusão: Evidenciou-se a necessidade de políticas públicas que proteja as crianças e as pessoas que estão em situação de vulnerabilidade.(AU)

Objective: describes an epidemiological situation of people who have been victims of abuse, neglect or abandonment in a state in northeastern Brazil. Method: This is an exploratory and descriptive study, with a quantitative approach and retrospective data, developed with data obtained from the Notifiable Diseases Information System. Results: The population comprised people attended and notified in the services themselves and under the Unified Health System, due to maltreatment, neglect or abandonment, between 2015 and 2018. It was observed that the majority were female (59, 6%), aged up to 9 years (56.4%) and residents of the urban area (79.1%). As for people who committed abuse, neglect or abandonment, the majority were female, had not drunk alcohol and violence was motivated by generational conflict (20%). Conclusion: The need for public policies to protect children and people who are in a situation of vulnerability was highlighted.(AU)

Objetivo: describe una situación epidemiológica de personas que han sido víctimas de abuso, negligencia o abandono en un estado del noreste de Brasil. Método: Se trata de un estudio exploratorio y descriptivo, con enfoque cuantitativo y datos retrospectivos, desarrollado con datos obtenidos del Sistema de Información de Enfermedades Notificables. Resultados: La población estuvo conformada por personas atendidas y notificadas en los propios servicios y en el Sistema Único de Salud, por maltrato, negligencia o abandono, entre 2015 y 2018. Se observó que la mayoría eran mujeres (59, 6%), de hasta 9 años (56,4%) y residentes del casco urbano (79,1%). En cuanto a las personas que cometieron maltrato, abandono o abandono, la mayoría eran mujeres, no habían bebido alcohol y la violencia estuvo motivada por conflicto generacional (20%). Conclusión: Se destacó la necesidad de políticas públicas para proteger a la niñez y a las personas en situación de vulnerabilidad.(AU)

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BACKGROUND: Essential oils (EO) extracted from Cinnamomum verum has been used as an antimicrobial agents for centuries. The effects of C. verum leaf oil against virulence of microorganisms is not well studied yet. OBJECTIVES: This study evaluates the effect of C. verum leaf oil against three virulence factors of Candida albicans, C. tropicalis and C. dubliniensis and its in-vivo toxicity. METHODS: Chemical composition of EO was determined using gas chromatography-mass spectrometry (GC-MS). Minimum inhibitory concentration (MIC) was determined using clinical and laboratory standards institute (CLSI) M27-A3 broth microdilution. Effect of EO on initial adhesion was quantified using XTT assay after allowing Candida cells to adhere to the polystyrene surface for 2 h. Biofilm formation of Candida in the presence of EO was quantified using XTT viability assay. Efficacy on reduction of germ tube formation was evaluated using standard protocol. Visualisation of biofilm formation and progression under the EO treatment were done using scanning electron microscope (SEM) and Time lapses microscope respectively. In-vivo toxicity of EO was determined using Galleria mellonella larvae. Chlorhexidine digluconate: positive control. RESULTS: Eugenol was the main compound of EO. MIC was 1.0 mg/mL. 50% reduction in initial adhesion was achieved by C. albicans, C. tropicalis and C. dubliniensis with 1.0, > 2.0 and 0.34 mg/mL respectively. 0.5 and 1.0 mg/mL significantly inhibit the germ tube formation. MBIC50 for forming biofilms were ≤ 0.35 mg/mL. 1.0 mg/mL prevent biofilm progression of Candida. SEM images exhibited cell wall damages, cellular shrinkages and decreased hyphal formation. No lethal effect was noted with in-vivo experiment model at any concentration tested. CONCLUSION: C. verum leaf oil acts against virulence factors of Candida and does not show any toxicity.

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Objetivo: Verificar os fatores associados à insegurança alimentar e nutricional (IAN) de uma comunidade carente. Métodos: Estudo transversal e analítico, desenvolvido nos meses de agosto e setembro de 2018, com 150 indivíduos, em uma comunidade carente de São Luís, Maranhão, Brasil. Participaram da pesquisa maiores de 18 anos, de ambos os sexos e residentes em domicílios na comunidade escolhida. Não foi incluído mais de um indivíduo por domicílio. Aplicou-se um questionário para obtenção de dados sociodemográficos (sexo, idade, escolaridade, renda, cor da pele, número de moradores da residência, estado civil e ocupação). A situação de insegurança alimentar e nutricional foi avaliada com auxílio da Escala Brasileira de Insegurança Alimentar, que mede a percepção e a experiência familiar da segurança alimentar, insegurança e fome em nível domiciliar, classificando o domicílio em segurança ou insegurança alimentar (leve, moderada ou grave). Realizou-se análise multivariada pelo modelo de regressão de Poisson. Resultados: A prevalência de IAN foi de 94% (n=141) nos avaliados. No que se refere à renda, 70,7% (n=106) tinham renda mensal menor que um salário mínimo. Quanto à escolaridade, 50,7% (n=76) relataram tempo inferior a oito anos de estudo. Observou-se associação em ter renda familiar menor que um salário mínimo (IRR=1,07; IC=1,07-1,31) com a IAN. Conclusão: A prevalência de insegurança alimentar foi elevada entre os indivíduos investigados e mostrou-se associada à menor renda.

Objective: To verify the factors associated with Food and Nutrition Insecurity (FNI) in a needy community. Methods: This analytical cross-sectional study was conducted from August to September 2018 with 150 people from a needy community in São Luís, Maranhão, Brazil. Participants were 18 years old, of both sexes, and lived in households in the chosen community. No more than one person per household was included. A questionnaire was used to obtain sociodemographic data (sex, age, education, income, skin color, number of people living in the household, marital status and occupation). Food and nutrition insecurity status was assessed by the Brazilian Food Insecurity Scale, which measures family's perception and experience of food security, insecurity and hunger in the household and classifies the household as either food security or food insecurity (mild, moderate or severe). Multivariate analysis was performed using the Poisson regression model. Results: The prevalence rate of FNI was 94% (n=141) in the people analyzed. Regarding income, 70.7% (n=106) of the participants had a monthly income of less than one minimum wage. As for education, 50.7% (n=76) of the participants reported having less than eight years of study. There was an association between household income of less than one minimum wage (IRR=1.07; CI=1.07-1.31) and FNI. Conclusion: The prevalence of food insecurity was high among the people analyzed and it was associated with lower income.

Objetivo: Verificar los factores asociados con la inseguridad alimentaria y nutricional (IAN) de una comunidad desfavorecida. Métodos: Estudio transversal y analítico desarrollado en los meses entre agosto y septiembre de 2018 con 150 individuos de una comunidad desfavorecida de São Luís, Maranhão, Brasil. Mayores de 18 años, de ambos los sexos y residentes de domicilios de la comunidad elegida participaron de la investigación. No se ha incluido más de uno individuo de cada domicilio. Se aplicó una encuesta para obtener los datos sociodemográficos (el sexo, la edad, la escolaridad, la renta, el color de la piel, el número de personas de la vivienda, el estado civil y la ocupación). La situación de inseguridad alimentaria y nutricional ha sido evaluada por la Escala Brasileña de Inseguridad Alimentaria que mide la percepción y la experiencia de la familia sobre la seguridad alimentaria, la inseguridad y el hambre a nivel domiciliario clasificándole de seguridad o inseguridad alimentaria (leve, moderada o grave). Se realizó un análisis multivariado por el modelo de regresión de Poisson. Resultados: La prevalencia de IAN en los evaluados ha sido del 94% (n=141). Sobre la renta, el 70,7% (n=106) tenía la renta mensual de menos de un sueldo mínimo. Respecto la escolaridad, el 50,7% (n=76) ha relatado haber tenido menos de ocho años de estudio. Se observó la asociación entre tener la renta familiar de menos de un sueldo mínimo (IRR=1,07; IC=1,07-1,31) y la IAN. Conclusión: La prevalencia de inseguridad alimentaria ha sido elevada entre los individuos investigados y se ha asociado con la renta baja.

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