Effects of bioflavonoid ternatin on liver regeneration and oxidative stress in rats
Acta cir. bras.
; 28(6): 435-440, 2013. ilus
Article
em En
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| ID: vti-9002
Biblioteca responsável:
BR1.1
Localização: BR68.1
ABSTRACT
PURPOSE:
To evaluate the effect of bioflavonoid ternatin (TRT) on rat liver regeneration and oxidative stress after 70% partial hepatectomy (PH).METHODS:
Thirty six young male Wistar rats were randomly assigned to two groups of 18 animals each - control (G1) and experimental (G2) - and were submitted to PH under inhalatory diethylether anesthesia. G1 rats received daily intraperitoneal (ip) injections of saline (NaCl 0.9% solution) 0.1 mL/kg for 14 days; G2 animals received daily ip injections of TRT 0.1% 1.0mg/kg for 14 days. At 36h (T1), 168h (T2) and 336h (T3) post-PH timepoints, a subgroup of six rats in each group was chosen in a randomized way to complementary hepatectomy (CH) and blood samples haversting. Collected material was saved for laboratory analysis (total bilirubin (TB), D-Glucose, glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) and assessment of liver regeneration.RESULTS:
TRT induced a significant decrease in liver and plasma GSH concentrations; liver regeneration process was not affected. TRT promoted a significant decrease in blood glucose levels 168h after partial hepatectomy compared with controls. TB levels remained unchanged.CONCLUSION:
Intraperitoneal bioflavonoid ternatin injection in partially hepatectomized rats induces a decrease in oxidative stress and a significant hypoglycemic state, but does not promote any change in the evolution of liver regeneration.(AU)Palavras-chave
Texto completo:
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Base de dados:
VETINDEX
Assunto principal:
Estresse Oxidativo
/
Hipoglicemia
/
Regeneração Hepática
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras.
Ano de publicação:
2013
Tipo de documento:
Article