Your browser doesn't support javascript.
loading
Does propofol and isoflurane protect the kidney against ischemia/reperfusion injury during transient hyperglycemia?
Carraretto, Antônio Roberto; Vianna Filho, Pedro Thadeu Galvão; Castiglia, Yara Marcondes Machado; Golim, Marjorie de Assis; Souza, Aparecida Vitória Gonçalves de; Carvalho, Lídia Raquel de; Deffune, Elenice; Vianna, Pedro Thadeu Galvão.
Afiliação
  • Carraretto, Antônio Roberto; Universidade Estadual Paulista. Botucatu. Brasil
  • Vianna Filho, Pedro Thadeu Galvão; Universidade Estadual Paulista. Departamento de Anestesiologia. Laboratório Experimental. Botucatu. Brasil
  • Castiglia, Yara Marcondes Machado; Universidade Estadual Paulista. Departamento de Anestesiologia. Botucatu. Brasil
  • Golim, Marjorie de Assis; Universidade Estadual Paulista. Departamento de Medicina. Botucatu. Brasil
  • Souza, Aparecida Vitória Gonçalves de; Universidade Estadual Paulista. Botucatu. Brasil
  • Carvalho, Lídia Raquel de; Universidade Estadual Paulista. Departamento de Estatística. Botucatu. Brasil
  • Deffune, Elenice; Universidade Estadual Paulista2Departamento de Medicina. Botucatu <.
  • Vianna, Pedro Thadeu Galvão; Universidade Estadual Paulista. Departamento de Anestesiologia. Botucatu. Brasil
Acta cir. bras. ; 28(3): 161-166, 2013. graf, tab
Article em En | VETINDEX | ID: vti-8969
Biblioteca responsável: BR1.1
Localização: BR68.1
ABSTRACT

PURPOSE:

To study the effect of isoflurane (Iso) or propofol (Prop) anesthesia on renal ischemia/reperfusion injury (IRI) during transient hyperglycemia.

METHODS:

Thirty six rats were randomly assigned into six groups of six animals each PHS (Sham-Prop=1mg.kg-1.min-1 + Hyperglycemia=2.5g.kg-1 of glucose solution administered intraperitoneally); HIS (Sham-Iso + Hyperglycemia); PHI (Prop + Hyperglycemia + Ischemia); IHI (Iso + Hyperglycemia + Ischemia); PI (Prop + Ischemia), and II (Iso + Ischemia). After 30 minutes of anesthesia induction, right nephrectomy was performed (all animals) and the left renal artery was clamped during 25 minutes (ischemia). The animals were sacrificed after 24 hours and blood collection (to dose creatinine) and left kidney removal were performed for histological analysis, and flow cytometry (FCM) percentage of initial apoptosis (APTi) and viable cells (VC).

RESULTS:

Serum creatinine (mg/dL) was statistically different in groups PHI (3.60±0.40) and IHI (3.23±1.08), p<0.05. Histological analysis was statistically different in groups PHI (4.0[4.0;5.0]) and IHI (4.5[4.0;5.0]), p<0.05. APTi percentage was statistically different in groups PHI (73.2±7.1), and IHI (48.1±14). VC percentage was statistically different in groups PHI (25.8±6.9) and IHI (38.5±9.2), p<0.05.

CONCLUSIONS:

Propofol and isoflurane showed the same level of protection against ischemia/reperfusion injury in the normoglycemic groups. Transient hyperglycemia is associated with an increase in IRI.(AU)
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Propofol / Isquemia / Rim Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2013 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Propofol / Isquemia / Rim Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2013 Tipo de documento: Article