Your browser doesn't support javascript.
loading
Probiotic Lactobacilli Improved Growth Performance and Attenuated Salmonella Typhimurium Infection Via Jak/Stat Signaling in Broilers
Shi, H; Deng, X; Deng, Q; Liu, Z; Liu, N.
Afiliação
  • Shi, H; University of Georgia. Department of Poultry Science. Athens. Estados Unidos da América
  • Deng, X; National Engineering Research Center of Biological Feed. Beijing. China
  • Deng, Q; Henan University of Science and Technology. Department of Animal Science. Luoyang. China
  • Liu, Z; Henan University of Science and Technology. Department of Animal Science. Luoyang. China
  • Liu, N; ational Engineering Research Center of Biological Feed. Beijing. China
R. bras. Ci. avíc. ; 23(1): eRBCA-2020-1328, fev. 2021. tab
Article em En | VETINDEX | ID: vti-762130
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT
This study aimed to investigate the effect of Lactobacillus plantarum DPP8 and Lactobacillus acidophilus C7282 in feed supplementation on growth performance, Salmonella invasion, inflammation, and mediating signaling in broilers infected with Salmonella Typhimurium (S. Typhimurium). A total of 240 broilers at day old were randomly allocated into four groups, orally infected with S. Typhimurium and supplemented with individual or combined Lactobacilli DPP8 and C7282 at doses of 0 (control), 1010 (individual), or 2.0 × 1010 (combination) cfu/kg of diet for 21 d. The results showed that supplementing Lactobacilli improved (p 0.05) feed intake and body weight gain and decreased (p 0.05) S. Typhimurium load in the caecum, harder gland, spleen and bursa of Fabricius. Also, the supplements decreased (p 0.05) interleukin (1/2/4), tumor necrosis factor and interferon in the serum, enhanced (p 0.05) interleukin 10, and downregulated gene expressions of inflammatory mediators including Janus kinase (Jak2/3), signal transducer and activator of transcription protein (STAT3/4/5/6) in the intestinal mucosa. In contrast, diets containing DPP8 exhibited greater effects on the inhibition of the pathogen and inflammatory response than C7282. The obtained data suggest that Lactobacilli C7282 and DPP8 can be used as feed additives to inhibit colonization and translocation of S. Typhimurium and inflammatory responses via downregulating Jak/STAT signaling in broilers.(AU)
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Intoxicação Alimentar por Salmonella / Galinhas / Lactobacillus Limite: Animals Idioma: En Revista: R. bras. Ci. avíc. / Rev. bras. ciênc. avic Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Intoxicação Alimentar por Salmonella / Galinhas / Lactobacillus Limite: Animals Idioma: En Revista: R. bras. Ci. avíc. / Rev. bras. ciênc. avic Ano de publicação: 2021 Tipo de documento: Article