Cholecystectomy during ceftriaxone therapy. A translational study with a new rabbit model
Acta cir. bras.
; 32(12): 995-1005, dez. 2017. ilus, tab, graf
Article
em En
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| ID: vti-728525
Biblioteca responsável:
BR68.1
Localização: BR68.1
ABSTRACT
Purpose:
To evaluate the actual incidence of both microlithiasis and acute cholecystitis during treatment with intravenous ceftriaxone in a new rabbit model.Methods:
New Zealand rabbits were treated with intravenous ceftriaxone or saline for 21 days. Ultrasound monitoring of the gallbladder was performed every seven days until the 21st day when histopathology, immunohistochemistry for proliferating cell nuclear antigen (PCNA), pro-caspase-3 and CD68, liver enzyme biochemistry, and chromatography analysis of the bile and sediments were also performed.Results:
All animals treated with ceftriaxone developed acute cholecystitis, confirmed by histopathology (P < 0.05) and biliary microlithiasis, except one that exhibited sediment precipitation. In the group treated with ceftriaxone there was an increase in pro-caspase-3, gamma-glutamyl transpeptidase concentration, PCNA expression and in the number of cells positive for anti-CD68 (P < 0.05). In the ceftriaxone group, the cholesterol and lecithin concentrations increased in the bile and a high concentration of ceftriaxone was found in the microlithiasis.Conclusion:
Ceftriaxone administered intravenously at therapeutic doses causes a high predisposition for lithogenic bile formation and the development of acute lithiasic cholecystitis.(AU)Palavras-chave
Texto completo:
1
Base de dados:
VETINDEX
Assunto principal:
Ceftriaxona
/
Colelitíase
/
Colecistite Aguda
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras.
Ano de publicação:
2017
Tipo de documento:
Article