Your browser doesn't support javascript.
loading
Effect of propolis extract on guines pig lung mast cell
O. Orsi, R.; M. Sforcin, J.; R. C. Funari, S.; C. Gomes, J..
Afiliação
  • O. Orsi, R.; UNESP School of Veterinary Medicine and Animal Husbrandy Department of Animal Production.
  • M. Sforcin, J.; UNESP Institute of Biosciences Department of Microbiology and Immunology.
  • R. C. Funari, S.; UNESP School of Veterinary Medicine and Animal Husbrandy Department of Animal Production.
  • C. Gomes, J.; UNESP Institute of Biosciences Department of Pharmacology.
J. Venom. Anim. Toxins incl. Trop. Dis. ; 11(1)2005.
Article em En | VETINDEX | ID: vti-442999
Biblioteca responsável: BR68.1
ABSTRACT
The direct effect of ethanolic extract of propolis on guinea pig lung cell suspension containing mast cells, as well as its influence on the histamine release induced by antigen (ovoalbumin 10 mug/ml) and ionophore A 23187 (3 muM) were investigated. Propolis ethanolic extract (300 mug/ml) increased the histamine release in guinea pig lung suspension containing mast cells by a cytotoxic effect. Lower concentrations of propolis had no effect on histamine release. Our results demonstrated that propolis (3, 10, 30, and 100 mug/ml) shows no significant effect on the histamine release induced by ionophore and antigen. Based on these results, we suggest that propolis could directly activate mast cells, promoting inflammatory mediators release by cytotoxic mechanisms, what could be related to allergic processes in propolis sensitive people.
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: J. Venom. Anim. Toxins incl. Trop. Dis. Ano de publicação: 2005 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Base de dados: VETINDEX Idioma: En Revista: J. Venom. Anim. Toxins incl. Trop. Dis. Ano de publicação: 2005 Tipo de documento: Article