Hypertrophy of NADH-diaphorase positive myenteric neurons in rat jejunum after acute infection caused by Toxoplasma gondii
J. Venom. Anim. Toxins incl. Trop. Dis.
; 16(2): 298-310, 2010. ilus, graf, tab
Article
em En
| VETINDEX
| ID: vti-4276
Biblioteca responsável:
BR68.1
Localização: BR68.1
ABSTRACT
Toxoplasmosis, a globally distributed feline-associated zoonosis caused by the protozoan Toxoplasma gondii, affects birds and mammals, including humans. This study assesses the consequences of acute T. gondii infection for NADH-diaphorase positive myenteric neurons in rat jejunum. Ten male Wistar rats (Rattus norvegicus) were divided into two groups G1 (n = 5) and G2 (n = 5). Animals from G2 were orally inoculated with 500 genotype III (M7741) T. gondii oocysts. Twenty-four hours after inoculation, the animals were euthanized and had their jejuna removed, through laparotomy, and measured (length and width) to calculate their areas. Intestinal segments were submitted to NADH-diaphorase histochemistry to evidence the most metabolically active subpopulation of myenteric neurons. No changes were found in body weight; intestinal length, width or area; or neuron population density. Increase of body cell area and cytoplasm and decrease of nuclear area of the myenteric neurons of infected animals were observed by morphometric analysis.(AU)
Palavras-chave
Texto completo:
1
Base de dados:
VETINDEX
Assunto principal:
Toxoplasma
/
Di-Hidrolipoamida Desidrogenase
Limite:
Animals
Idioma:
En
Revista:
J. Venom. Anim. Toxins incl. Trop. Dis.
Ano de publicação:
2010
Tipo de documento:
Article