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Serological under expression of microRNA-21, microRNA-34a and microRNA-126 in colorectal cancer
Almeida, Ana Luiza Normanha Ribeiro de; Bernardes, Mário Vinícius Angelete Alvarez; Feitosa, Marley Ribeiro; Peria, Fernanda Maris; Tirapelli, Daniela Pretti da Cunha; Rocha, José Joaquim Ribeiro da; Feres, Omar.
Afiliação
  • Almeida, Ana Luiza Normanha Ribeiro de; University of São Paulo. Ribeirão Preto Medical School. Department of Surgery and Anatomy. Division of Coloproctology. Ribeirão Preto. Brasil
  • Bernardes, Mário Vinícius Angelete Alvarez; University of São Paulo. Ribeirão Preto Medical School. Department of Surgery and Anatomy. Ribeirão Preto. Brasil
  • Feitosa, Marley Ribeiro; University of São Paulo. Ribeirão Preto Medical School. Department of Surgery and Anatomy. Division of Coloproctology. Ribeirão Preto. Brasil
  • Peria, Fernanda Maris; University of São Paulo. Ribeirão Preto Medical School. Division of Clinical Oncology. Ribeirão Preto. Brasil
  • Tirapelli, Daniela Pretti da Cunha; University of São Paulo. Ribeirão Preto Medical School. Department of Surgery and Anatomy. Ribeirão Preto. Brasil
  • Rocha, José Joaquim Ribeiro da; University of São Paulo. Ribeirão Preto Medical School. Department of Surgery and Anatomy. Ribeirão Preto. Brasil
  • Feres, Omar; University of São Paulo. Ribeirão Preto Medical School. Department of Surgery and Anatomy. Ribeirão Preto. Brasil
Acta cir. bras. ; 31(supl.1): 13-18, 2016. ilus, tab
Article em En | VETINDEX | ID: vti-341439
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

PURPOSE:

This paper describes the ability of miRNA value predict oncological outcomes in CRC patients and correlates to clinical and pathologic variables.

METHODS:

We prospectively analyzed the serological expression of microRNA-21, microRNA-34a, and microRNA-126 in 37 stage II - IV CRC patients and correlate to seven fit counterparts. Serological microRNAs were extracted using the miRNeasy Mini Kit(r) (Qiagen, Hilden, Germany). Quantification of microRNAs was performed using TaqMan Master Mix(r) reagent (Applied Biosystems, USA).

RESULTS:

We obtained serological underexpression microRNA-21, microRNA-34a, and microRNA-126 in CRC group. However, miRNAs serological values do not impact prognosis. Furthermore, miRNAs was not influenced by CEA values, TNM staging, and histological subtype.

CONCLUSION:

Despite lower expression of miR-21, miR-34a and miR-126 in the CRC group, no association with poor prognosis was found.(AU)
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Texto completo: 1 Base de dados: VETINDEX Assunto principal: Neoplasias Colorretais / MicroRNAs Limite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Acta cir. bras. Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Neoplasias Colorretais / MicroRNAs Limite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Acta cir. bras. Ano de publicação: 2016 Tipo de documento: Article