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Analysis of systemic and cutaneous inflammatory immune response in canine atopic dermatitis
Ferreira, Tiago Cunha; Lima-Verde, Juliana Furtado; Silva Júnior, José Alexandre da; Ferreira, Társsila Mara Vieira; Viana, Daniel de Araújo; Nunes-Pinheiro, Diana Célia Sousa.
Afiliação
  • Ferreira, Tiago Cunha; Universidade Estadual do Ceará. Faculdade de Veterinária. Laboratório de Imunologia e Bioquímica Animal. Fortaleza. Brazil
  • Lima-Verde, Juliana Furtado; Universidade Estadual do Ceará. Faculdade de Veterinária. Laboratório de Imunologia e Bioquímica Animal. Fortaleza. Brazil
  • Silva Júnior, José Alexandre da; Universidade Estadual do Ceará. Faculdade de Veterinária. Laboratório de Imunologia e Bioquímica Animal. Fortaleza. Brazil
  • Ferreira, Társsila Mara Vieira; Universidade Estadual do Ceará. Faculdade de Veterinária. Laboratório de Imunologia e Bioquímica Animal. Fortaleza. Brazil
  • Viana, Daniel de Araújo; Laboratório PATHOVET. Fortaleza. Brazil
  • Nunes-Pinheiro, Diana Célia Sousa; Universidade Estadual do Ceará. Faculdade de Veterinária. Laboratório de Imunologia e Bioquímica Animal. Fortaleza. Brazil
Acta sci. vet. (Online) ; 49: Pub. 1782, Jan. 18, 2021. ilus, tab
Article em En | VETINDEX | ID: vti-29816
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

Background:

Canine atopic dermatitis (CAD) is a chronic and inflammatory disease present in veterinary dermatologicalpractice. The inflammation in CAD is triggered by environmental allergens and skin microorganisms, which are responsiblefor the worsening of cutaneous lesions. This continuous activation of skin inflammatory process can induce the productionof free radicals that also contribute to cellular damage and ultimately leads to changes in blood parameters in dogs withCAD. Although there are reports of inflammatory parameters in CAD, there are a lack of studies correlating skin lesions,blood leukocytes and oxidative stress. Based on that, this study aimed to evaluate the integumentary and systemic inflammatory response in dogs with atopic dermatitis.Materials, Methods &

Results:

Dogs with confirmed diagnosis of canine atopic dermatitis (n = 10) were divided in twogroups according to CADESI-IV AI, with CADESI between 0-10, AII, with CADESI between 10-34, and control group (n= 5). Blood-biochemical and histological analysis were performed to access systemic and cutaneous inflammatory response.AII group tended to higher neutrophil and eosinophil counts, as well as neutrophil/lymphocyte ratio (NLR) when comparedto AI. The albumin was lower in AII compared to AI and control (P < 0.05), while total bilirubin and malondialdehyde(MDA) did not differ between groups. NLR (r = 0.64 and P = 0.04) and MDA (r = 0.54 and P = 0.1) were positively correlated with CADESI, while albumin was negatively correlated with CADESI (r = -0.79 and P = 0.005). Histopathologicalanalysis revealed a larger number of neutrophils, macrophages and mast cells in AI and AII than in control group (P < 0.05).

Discussion:

In this study it was possible to evaluate the systemic and cutaneous leukocyte dynamics in CAD. Skin inflammation induces the production of chemotactic molecules contribute to neutrophil outflow from blood vessel toward the...(AU)
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Texto completo: 1 Base de dados: VETINDEX Assunto principal: Dermatite Atópica / Cães Limite: Animals Idioma: En Revista: Acta sci. vet. (Impr.) / Acta sci. vet. (Online) Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Dermatite Atópica / Cães Limite: Animals Idioma: En Revista: Acta sci. vet. (Impr.) / Acta sci. vet. (Online) Ano de publicação: 2021 Tipo de documento: Article