Poly (lactic acid) membrane and Sedum dendroideum extract favors the repair of burns in rats
Acta cir. bras.
; 35(3): e202000302, May 11, 2020. ilus, tab
Article
em En
| VETINDEX
| ID: vti-29327
Biblioteca responsável:
BR68.1
Localização: BR68.1
ABSTRACT
Purpose:
To evaluate the healing potential of the electrospinning membranes of Poly (Lactic Acid) (PLA) associated with Sedum dendroideum extract in burn injuries in rats.Methods:
Seventy-five rats were submitted to burn injury on their back skin (C) untreated; (F) with daily topical application of S. dendroideum extract; (M) with electrospinning membranes of PLA; (MF10) with electrospinning membranes of PLA with 10% S. dendroideum extract; (MF25) with electrospinning membranes of PLA with 25% S. dendroideum extract. Tissue samples were taken after 2, 6 and 14 days of the burn injury and were subjected to histomorfometric analysis of quantification of fibroblasts, collagen fibers, blood vessels, and inflammatory infiltrateResults:
The histomorphometric analysis showed an increase in the number of fibroblasts, collagen fibers and blood vessels in the burns treated with membranes of PLA, associated or not with the 10% and 25% extract. The extract of S. dendroideum promoted the increase of collagen fibers.Conclusion:
The electrospinning PLA membrane, isolated or associated with the S. dendrodeum extract, favored the healing of burn injuries in this experimental model, with an increase of fibroblasts, collagen fibers, and blood vessels. S. dendroideum isolated only stimulated the collagenesis.(AU)Palavras-chave
Texto completo:
1
Base de dados:
VETINDEX
Assunto principal:
Pele
/
Cicatrização
/
Queimaduras
/
Ácido Láctico
/
Sedum
/
Membranas
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras.
Ano de publicação:
2020
Tipo de documento:
Article