Prevention of bone infection after open fracture using a chitosan with ciprofloxacin implant in animal model
Acta cir. bras.
; 35(8): e202000803, 2020. ilus, tab
Article
em En
| VETINDEX
| ID: vti-28594
Biblioteca responsável:
BR68.1
Localização: BR68.1
ABSTRACT
Purpose To evaluate different concentrations of ciprofloxacin to prevent infection after open fracture contaminated with S. aureus in rats using absorbable local delivery system. Methods Fifty-two Wistar rats were assigned to six groups. After 4 weeks, all animals underwent 99mTc-ceftizoxima scintigraphy evaluation, callus formation measurement and histological analysis. ANOVA, t-Student and Kruskal Wallis were used for quantitative variables statistical analysis, whereas qui square and exact Fisher were used for qualitative variables. Results Treatment using 25% and 50% of ciprofloxacin incorporated at the fracture fixation device were effective in preventing bone infection compared to control group (p<0.05). Chitosan were not effective in preventing bone infection when used alone compared to control group (p>0.05). Histological findings demonstrated bone-healing delay with 50% of ciprofloxacin. No difference in callus formation were observed (p>0.05). Conclusion Local delivery treatment for contaminated open fracture using chitosan with ciprofloxacin is effective above 25%.(AU)
Palavras-chave
Texto completo:
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Base de dados:
VETINDEX
Assunto principal:
Osteíte
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Ciprofloxacina
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Quitosana
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Fraturas do Fêmur
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Fraturas Expostas
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras.
Ano de publicação:
2020
Tipo de documento:
Article