Your browser doesn't support javascript.
loading
Prevention of bone infection after open fracture using a chitosan with ciprofloxacin implant in animal model
Kobata, Silvia Iovine; Teixeira, Luiz Eduardo Moreira; Fernandes, Simone Odilia Antunes; Faraco, André Augusto Gomes; Vidigal, Paula Vieira Teixeira; Araújo, Ivana Duval de.
Afiliação
  • Kobata, Silvia Iovine; s.af
  • Teixeira, Luiz Eduardo Moreira; Universidade Federal de Minas Gerais. Medical School. Locomotor System Department. Belo Horizonte. Brazil
  • Fernandes, Simone Odilia Antunes; Universidade Federal de Minas Gerais. Medical School. Department of Pharmacy. Belo Horizonte. Brazil
  • Faraco, André Augusto Gomes; Universidade Federal de Minas Gerais. Medical School. Department of Pharmacy. Belo Horizonte. Brazil
  • Vidigal, Paula Vieira Teixeira; Universidade Federal de Minas Gerais. Medical School. Histopathology Department. Belo Horizonte. Brazil
  • Araújo, Ivana Duval de; Universidade Federal de Minas Gerais. Medical School. Surgery Department. Belo Horizonte. Brazil
Acta cir. bras. ; 35(8): e202000803, 2020. ilus, tab
Article em En | VETINDEX | ID: vti-28594
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT
Purpose To evaluate different concentrations of ciprofloxacin to prevent infection after open fracture contaminated with S. aureus in rats using absorbable local delivery system. Methods Fifty-two Wistar rats were assigned to six groups. After 4 weeks, all animals underwent 99mTc-ceftizoxima scintigraphy evaluation, callus formation measurement and histological analysis. ANOVA, t-Student and Kruskal Wallis were used for quantitative variables statistical analysis, whereas qui square and exact Fisher were used for qualitative variables. Results Treatment using 25% and 50% of ciprofloxacin incorporated at the fracture fixation device were effective in preventing bone infection compared to control group (p<0.05). Chitosan were not effective in preventing bone infection when used alone compared to control group (p>0.05). Histological findings demonstrated bone-healing delay with 50% of ciprofloxacin. No difference in callus formation were observed (p>0.05). Conclusion Local delivery treatment for contaminated open fracture using chitosan with ciprofloxacin is effective above 25%.(AU)
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Osteíte / Ciprofloxacina / Quitosana / Fraturas do Fêmur / Fraturas Expostas Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Osteíte / Ciprofloxacina / Quitosana / Fraturas do Fêmur / Fraturas Expostas Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2020 Tipo de documento: Article