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Local effect of simvastatin combined with different osteoconductive biomaterials and collagen sponge on new bone formation in critical defects in rat calvaria
Sousa, Dircilei Nascimento de; Roriz, Virgílio Moreira; Oliveira, Guilherme José Pimentel Lopes de; Duarte, Wagner Rodrigues; Pinto, Leonardo Nogueira de Miranda Pereira; Vianna, Leonora Maciel de Souza; Carneiro, Fabiana Pirani; Ferreira, Vania Maria Moraes.
Afiliação
  • Sousa, Dircilei Nascimento de; Universidade de Brasília. School of Medicine. Brazil
  • Roriz, Virgílio Moreira; Universidade Federal de Goiás. Faculty of Dentistry. Goiania. Brazil
  • Oliveira, Guilherme José Pimentel Lopes de; Universidade Federal de Uberlândia. Faculty of Dentistry. Uberlândia. Brazil
  • Duarte, Wagner Rodrigues; Universidade de Brasília. Faculty of Dentistry. Brasília. Brazil
  • Pinto, Leonardo Nogueira de Miranda Pereira; Universidade de Brasília. Faculty of Dentistry. Brasília. Brazil
  • Vianna, Leonora Maciel de Souza; Universidade de Brasília. School of Medicine. Brasília. Brazil
  • Carneiro, Fabiana Pirani; Universidade de Brasília. School of Medicine. Brasília. Brazil
  • Ferreira, Vania Maria Moraes; Universidade de Brasília. School of Medicine. Brasília. Brazil
Acta cir. bras. ; 35(1): e202000102, Mar. 20, 2020. ilus
Article em En | VETINDEX | ID: vti-25691
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT
Purpose To evaluate the local effect of simvastatin (SVT) combined with deproteinized bovine bone (DBB) with hydroxyapatite/β-tricalcium phosphate biphasic ceramics (HA/TCP) and with collagen sponge (CS) on bone repair in critical size defects (CSDs) in rat calvaria. Methods Forty-two 5-mm diameter CSDs were made bilaterally in the calvaria of 18 rats. The animals were allocated according to the type of biomaterial and associations used to fill the CSD. After 8 weeks, the animals were euthanized, and their calvaria were evaluated for repaired tissue composition using histologic and histometric analyses. Results In the histometric analysis, the use of SVT showed to increase bone formation in the CSDs when combined with all the bone substitutes tested in this study (p<0.05). Greater bone formation was observed in the groups with SVT compared to the groups without SVT. Conclusions The use of SVT without the need for a vehicle and combined with a commercially available biomaterial may be a cheaper way to potentiate the formation of bone tissue without the need to produce new biomaterials. Therefore, SVT combined with DBB induced significantly greater new bone formation than did the other treatments.(AU)
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Texto completo: 1 Base de dados: VETINDEX Assunto principal: Materiais Biocompatíveis / Regeneração Óssea / Colágeno / Sinvastatina Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: VETINDEX Assunto principal: Materiais Biocompatíveis / Regeneração Óssea / Colágeno / Sinvastatina Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2020 Tipo de documento: Article