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Effects of tadalafil to prevent injury on corpus cavernosum after vascular or nervous peri-prostatic bundle injury. Experimental model in rats
Toledo, Antônio Carlos de; Kawano, Paulo Roberto; Yamamoto, Hamilto Akihissa; Guerra, Rodrigo; Gomes Filho, Fernando Ferreira; Pajolli, Pedro Ivo Rochetti; Amaro, João Luiz; Cardoso, Luiz Eduardo Macedo; Sampaio, Francisco José.
Afiliação
  • Toledo, Antônio Carlos de; Universidade Estadual Paulista. Botucatu School of Medicine. Botucatu. Brasil
  • Kawano, Paulo Roberto; Universidade Estadual Paulista. Botucatu School of Medicine. Department of Urology. Botucatu. Brasil
  • Yamamoto, Hamilto Akihissa; Universidade Estadual Paulista. Botucatu School of Medicine. Department of Urology. Botucatu. Brasil
  • Guerra, Rodrigo; Universidade Estadual Paulista. Botucatu School of Medicine. Department of Urology. Botucatu. Brasil
  • Gomes Filho, Fernando Ferreira; Universidade Estadual Paulista. Botucatu School of Medicine. Botucatu. Brasil
  • Pajolli, Pedro Ivo Rochetti; Universidade Estadual Paulista. Botucatu School of Medicine. Department of Urology. Botucatu. Brasil
  • Amaro, João Luiz; Universidade Estadual Paulista. Botucatu School of Medicine. Department of Urology. Botucatu. Brasil
  • Cardoso, Luiz Eduardo Macedo; Universidade Estadual do Rio de Janeiro. Urogenital Research Unit. Brazil
  • Sampaio, Francisco José; Universidade Estadual do Rio de Janeiro. Urogenital Research Unit. Brazil
Acta cir. bras. ; 34(9): e201900901, Nov. 2019. tab
Article em En | VETINDEX | ID: vti-23999
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

Purpose:

To evaluate the effects of tadalafil (TD) in preventing histological alterations of the corpus cavernosum caused by isolated lesions of cavernous nerve (ILCN) and artery (ILCA) in rats.

Methods:

Fifty male Wistar rats were randomly assigned in five groups G1 control; G2 bilateral ILCN; G3 bilateral ILCA; G4 ILCN+TD; G5 ILCA+TD. The cavernous bodies were submitted to histomorphometry, immunohistochemistry and biochemical analysis.

Results:

Nerve density was significantly higher in G2 and G4 compared to control (22.62±2.84 and 19.53±3.47 vs. 15.72±1.82; respectively, p<0.05). Smooth muscle density was significantly lower in G2 and G3 in comparison to G1 (12.87±1.90 and 18.93±1.51 vs. 21.78±1.81, respectively; p<0.05). A significant decrease in the sinusoidal lumen area was observed in G2 compared to controls (5.01±1.62 vs. 9.88±3.66, respectively; p<0.05) and the blood vessel density was increased in G2 and G3 (29.32±4.13 e 20.80±2.47 vs. 10.13±2.71, p<0.05). Collagen density was higher in G3 compared to G1 (93.76±15.81 vs. 64.59±19.25; p<0.05).

Conclusions:

Histomorphometric alterations caused by ILCN were more intense than those produced by vascular injury, but the collagen analyses showed more fibrosis in animals with ILCA. TD was effective in preventing the majority of the alterations induced by the periprostatic bundle injury.(AU)
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Texto completo: 1 Base de dados: VETINDEX Assunto principal: Pênis / Tadalafila / Disfunção Erétil Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Pênis / Tadalafila / Disfunção Erétil Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2019 Tipo de documento: Article