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Mechanisms of the beneficial effect of sevoflurane in liver ischemia/reperfusion injury
Cavalcante, Fernanda Paula; Coelho, Ana Maria Mendonça; Machado, Marcel Cerqueira Cesar; Sampietre, Sandra Nassa; Patzina, Rosely Antunes; Diniz, Márcio Augusto; Chaib, Eleazar; D'Albuquerque, Luiz Augusto Carneiro.
Afiliação
  • Cavalcante, Fernanda Paula; Universidade de São Paulo. School of Medicine. Postgraduate Program in Gastroenterology. São Paulo. Brazil
  • Coelho, Ana Maria Mendonça; Universidade de São Paulo. School of Medicine. Department of Gastroenterology, Medical Investigation Laboratory. Division of Liver Transplantation. São Paulo. Brazil
  • Machado, Marcel Cerqueira Cesar; Universidade de São Paulo. School of Medicine. Department of Gastroenterology, Medical Investigation Laboratory. Division of Liver Transplantation. São Paulo. Brazil
  • Sampietre, Sandra Nassa; Universidade de São Paulo. School of Medicine. Department of Gastroenterology, Medical Investigation Laboratory. Division of Liver Transplantation. São Paulo. Brazil
  • Patzina, Rosely Antunes; Universidade de São Paulo. School of Medicine. Department of Pathology. São Paulo. Brazil
  • Diniz, Márcio Augusto; Universidade de São Paulo. School of Medicine. Department of Gastroenterology. São Paulo. Brazil
  • Chaib, Eleazar; Universidade de São Paulo. School of Medicine. Department of Gastroenterology, Medical Investigation Laboratory. Division of Liver Transplantation. São Paulo. Brazil
  • D'Albuquerque, Luiz Augusto Carneiro; Universidade de São Paulo. School of Medicine. Department of Gastroenterology, Medical Investigation Laboratory. Division of Liver Transplantation. São Paulo. Brazil
Acta cir. bras. ; 30(11): 749-755, Nov. 2015. ilus, tab, graf
Article em En | VETINDEX | ID: vti-23365
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT
To evaluate the underlying mechanisms by which sevoflurane protects the liver against ischemia/reperfusion injury evaluate the mechanism by which sevoflurane exerts this protective effect.

METHODS:

Twenty-six rats were subjected to partial ischemia/reperfusion injury for 1h one group received no treatment, one group received sevoflurane, and sham group of animals received laparotomy only. Four hours after reperfusion, levels of alanine and aspartate aminotransferases, tumor necrosis factor-a, and interleukins 6 and 10 were measured. Analyses of mitochondrial oxidation and phosphorylation, malondialdehyde content, histology, and pulmonary vascular permeability were performed.

RESULTS:

Serum levels of alanine and aspartate aminotransferases were significantly lower in the sevoflurane group compared to untreated controls (p 0.05). The sevoflurane group also showed preservation of liver mitochondrial function compared to untreated controls (p 0.05). Sevoflurane administration did not alter increases in serum levels of tumor necrosis factor-a, and interleukins 6 and 10. Sevoflurane treatment significantly reduced the coagulative necrosis induced by ischemia/reperfusion (p 0.05). Pulmonary vascular permeability was preserved in the sevoflurane group compared to untreated controls.

CONCLUSION:

Sevoflurane administration protects the liver against ischemia/reperfusion injury, via preservation of mitochondrial function, and also preserves lung vascular permeability.(AU)
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Texto completo: 1 Base de dados: VETINDEX Assunto principal: Traumatismo por Reperfusão / Citocinas / Sevoflurano / Fígado Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Traumatismo por Reperfusão / Citocinas / Sevoflurano / Fígado Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2015 Tipo de documento: Article