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Importance of duration and number of ischemic postconditioning cycles in preventing reperfusion mesenteric injuries. Experimental study in rats
Santos, Carlos Henrique Marques dos; Aydos, Ricardo Dutra; Neto, Ed Nogueira; Miiji, Luciana Nakao Odashiro; Cassino, Pedro Carvalho; Ahmed, Isadora Ishaq; Calheiros, Nadia Meneguesso; Garcia, Milena; Silva, Anderson Fernandes da.
Afiliação
  • Santos, Carlos Henrique Marques dos; Universidade Federal do Mato Grosso do Sul. Department of Surgery. Campo Grande. Brazil
  • Aydos, Ricardo Dutra; Universidade Federal do Mato Grosso do Sul. Department of Surgery. Campo Grande. Brazil
  • Neto, Ed Nogueira; Universidade Federal do Mato Grosso do Sul. Department of Surgery. Campo Grande. Brazil
  • Miiji, Luciana Nakao Odashiro; Universidade Federal do Mato Grosso do Sul. Department of Pathology. Campo Grande. Brazil
  • Cassino, Pedro Carvalho; Universidade Federal do Mato Grosso do Sul. Postgraduate Program in Health and Development in Region Midwest. Campo Grande. Brazil
  • Ahmed, Isadora Ishaq; Universidade Federal do Mato Grosso do Sul. School of Medicine. Campo Grande. Brazil
  • Calheiros, Nadia Meneguesso; Universidade Federal do Mato Grosso do Sul. School of Medicine. Campo Grande. Brazil
  • Garcia, Milena; Universidade Federal do Mato Grosso do Sul. School of Medicine. Campo Grande. Brazil
  • Silva, Anderson Fernandes da; Universidade Federal do Mato Grosso do Sul. Postgraduate Program in Health and Development in Region Midwest. Campo Grande. Brazil
Acta cir. bras. ; 30(10): 709-714, Oct. 2015. ilus, tab, graf
Article em En | VETINDEX | ID: vti-23328
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT
To evaluate the effect of ischemic postconditioning (IPC) on intestinal mucosa of rats subjected to ischemia and reperfusion process comparing two cycles of reperfusion and ischemia lasting two minutes each and four cycles of reperfusion and ischemia lasting 30 seconds each

METHODS:

Thirty Wistar rats were distributed into three groups group A (10 rats), ischemia (30 minutes) and reperfusion (60 minutes); group B (10 rats), ischemia and reperfusion plus IPC by two lasting two minutes each; and Group C (10 rats), ischemia and reperfusion plus IPC by four cycles lasting 30 seconds each. Finally, a segment of small intestine was resected for histological analysis. We analysed the results according to Chiu et al . classification and proceeded to the statistical treatment by Kruskal-Wallis test (p 0.05).

RESULTS:

The mean degree of tissue injury according to Chiu et al . classification were Group A, 2.77; in group B, 1.4; and group C, 1.4. B X C (p 0.05).

CONCLUSIONS:

Ischemic postconditioning was able to minimize reperfusion injury of rats undergone mesenteric ischemia and reperfusion process. There was no difference in the effectiveness of the method comparing two cycles of two minutes with four cycles of 30 seconds by H&E histological evaluation of the ileum after 60-minute reperfusion.(AU)
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Texto completo: 1 Base de dados: VETINDEX Assunto principal: Reperfusão / Pós-Condicionamento Isquêmico / Mucosa Intestinal Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Reperfusão / Pós-Condicionamento Isquêmico / Mucosa Intestinal Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2015 Tipo de documento: Article