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Deleterious effects of prepubertal corticosterone treatment on rat prostate
Pinto, Flávia Cristina Morone; Silva, Dílson; Silva, Pamella Campos; Pereira, Luiza Morone; Morone, Arlene Regina; Costa, Waldemar Silva; Cortez, Célia Martins; Sampaio, Francisco José Barcellos.
Afiliação
  • Pinto, Flávia Cristina Morone; Federal University of Pernambuco. Center for Health Sciences. Department of Surgery. Recife. BR
  • Silva, Dílson; State University of Rio de Janeiro. Department of Applied Mathematics. Rio de Janeiro. BR
  • Silva, Pamella Campos; State University of Rio de Janeiro. Urogenital Research Unit. Rio de Janeiro. BR
  • Pereira, Luiza Morone; Federal University of the State of Rio de Janeiro. Department of Physiology. Rio de Janeiro. BR
  • Morone, Arlene Regina; Federal University of the State of Rio de Janeiro. Department of Physiology. Rio de Janeiro. BR
  • Costa, Waldemar Silva; State University of Rio de Janeiro. Urogenital Research Unit. Rio de Janeiro. BR
  • Cortez, Célia Martins; State University of Rio de Janeiro. Department of Applied Mathematics. Postgraduate Program in Computer Science. Physical Modeling Group in Mathematical Biology. Rio de Janeiro. BR
  • Sampaio, Francisco José Barcellos; State University of Rio de Janeiro. Urogenital Research Unit. Rio de Janeiro. BR
Acta cir. bras ; Acta cir. bras;30(6): 383-387, 06/2015. tab, ilus
Article em En | LILACS, VETINDEX | ID: biblio-1456227
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

PURPOSE:

To investigate the structural and functional changes induced by corticosterone (CORT) in the ventral prostrate (VP) of rats in order to study chronic stress effects in the prepubertal phase.

METHODS:

Wistar rats received daily saline or CORT injections during the pubertal period from the 5th to 25th day of postnatal life. The animals were distributed into four groups 1 - Control (n=5); 2 - Control 99mTc-P (n=5); 3 - Treated with CORT (n=14); 4 - Treated with CORT and 99mTc-P (n=10). All rats were sacrificed at two months of age. Technical tissue uptakes of 99mTc-P were used to evaluate the functional and stereological methods for morphological analysis.

RESULTS:

Acini distribution in the group treated with CORT differed significantly (p 0.0001) from the control. The control group's epithelial average height (10.01±0.24 microns) was statistically significant (p 0.0001) from rats treated with CORT (19.27±0.73microns). The collagen distribution was lower in the treated group (2.79%) when compared to control (3.97%). The radioactivity percentage in the groups marked with 99mTc-P (%Ati/g) did not demonstrate a statistically significant difference (p=0.285897).

CONCLUSION:

Chronic administration of corticosterone in prepubertal rats causes changes in their acinar structure and their ventral prostate stroma, indicating possible deleterious effects of this hormone.
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Texto completo: 1 Coleções: 01-internacional Base de dados: VETINDEX / LILACS Assunto principal: Próstata / Corticosterona / Glucocorticoides Limite: Animals Idioma: En Revista: Acta cir. bras / Acta cir. bras. Assunto da revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
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Texto completo: 1 Coleções: 01-internacional Base de dados: VETINDEX / LILACS Assunto principal: Próstata / Corticosterona / Glucocorticoides Limite: Animals Idioma: En Revista: Acta cir. bras / Acta cir. bras. Assunto da revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil