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Therapeutic effect of low molecular weight chitosan containing sepia ink on ethanol-induced gastric ulcer in rats
Zhang, Wei; Liu, Kang; Li, Lei; Li, Yingxin; Sui, Xianxian; Rao, Yinzhu; Wu, Jiahao; Wu, Qiuping.
Afiliação
  • Zhang, Wei; Lingnan Normal University. Round Beibu Gulf Institute for the Protection and Utilization of Marine Animals in Medicine. China
  • Liu, Kang; Guangdong Ocean University. College of Fisheries. The Key Laboratory of nutrition and feed. China
  • Li, Lei; Lingnan Normal University. Life Science and Technology School. China
  • Li, Yingxin; Lingnan Normal University. Life Science and Technology School. China
  • Sui, Xianxian; Fudan University. Shanghai Medical College. Department of Pathology and Pathological Physiology. Shangai. China
  • Rao, Yinzhu; Lingnan Normal University. Round Beibu Gulf Institute for the Protection and Utilization of Marine Animals in Medicine. China
  • Wu, Jiahao; Lingnan Normal University. Life Science and Technology School. China
  • Wu, Qiuping; Lingnan Normal University. Life Science and Technology School. China
Acta cir. bras. ; 31(12): 813-820, Dec. 2016. ilus, graf
Article em En | VETINDEX | ID: vti-20994
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

PURPOSE:

To evaluate the role of low molecular chitosan containing sepia ink (LMCS) in ethanol-induced (5 ml/kg) gastric ulcer in rats.

METHODS:

Animals were divided into four groups (n = 12) normal group (Normal), negative control group (Con), experiment group (LMCS) and positive control Omeprazole group (OMZ). Gastric empty rate was detected in the first 7 days. Rats were sacrificed at 7, 14 and 21 day for histology and ELISA detections.

RESULTS:

Gastric empty was no significant differences among the groups (P > 0.05). Histological observation showed gastric mucosal LMCS treated had better healing effect. Hydroxyproline (Hyp) was significantly increased from 7 day (P < 0.05). LMCS significantly inhibited malondialdehyde (MDA) generation for lipid peroxidation from 7 day (P < 0.05). LMCS significantly promoted the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) at the earlier stage (P < 0.05). OMZ had the similar effects above. As for myeloperoxidase (MPO), LMCS significantly decreased and restored it to normal levels from 7 day (P < 0.05), it is earlier than OMZ which is from 14 day.

CONCLUSION:

LMCS can improve gastric mucosa tissue repair, exert significant influences on oxidative and antioxidant enzyme activities and neutrophil infiltration.(AU)
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Texto completo: 1 Base de dados: VETINDEX Assunto principal: Úlcera Gástrica / Quitosana / Sepia Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2016 Tipo de documento: Article / Project document
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Úlcera Gástrica / Quitosana / Sepia Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2016 Tipo de documento: Article / Project document