L-carnitine has a protective effect on the colonic mucosa during abdominopelvic radiotherapy in rats
Acta cir. bras.
; 31(9): 615-620, Sept. 2016. ilus
Article
em En
| VETINDEX
| ID: vti-20936
Biblioteca responsável:
BR68.1
Localização: BR68.1
ABSTRACT
PURPOSE:
To evaluate histopathologically the radioprotective effect of L-carnitine on the colonic mucosa in rats undergoing abdominopelvic irradiation.METHODS:
Thirty-two rats were randomly assigned to four experimental groups intraperitoneal administration of normal saline (group 1) or L-carnitine (300 mL/kg; group 2), followed in groups 3 and 4, respectively, by one dose of abdominopelvic radiation (20 Gy) 30 min later. Rats were sacrificed 5 days after radiation, and their descending colons were resected for histopathological evaluation of the presence and severity of damage.RESULTS:
Average damage scores did not differ significantly between groups 1 and 2 (0.13 ± 0.35 and 0.25 ± 0.46, respectively); the group 3 score was highest (10.25 ± 0.71), and the group 4 score (3.63 ± 1.41) was significantly lower than that of group 3 (both p = 0.0001). Pre-radiation L-carnitine administration significantly reduced mucosal thinning, crypt distortion, reactive atypia, inflammation, cryptitis, and reactive lymph-node hyperplasia (all p 0.01).CONCLUSIONS:
L-carnitine had a radioprotective effect on rat colonic mucosa. L-carnitine use should be explored for patients with gastrointestinal cancer, who have reduced serum L-carnitine levels.(AU)Palavras-chave
Texto completo:
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Base de dados:
VETINDEX
Assunto principal:
Protetores contra Radiação
/
Carnitina
/
Colo Descendente
/
Mucosa Intestinal
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras.
Ano de publicação:
2016
Tipo de documento:
Article