Beneficial effects of -glucan against cisplatin side effects on the nervous system in rats
Acta cir. bras.
; 31(3): 198-205, mar. 2016. tab, ilus
Article
em En
| VETINDEX
| ID: vti-20508
Biblioteca responsável:
BR68.1
Localização: BR68.1
ABSTRACT
PURPOSE:
To investigate the protective effect of Bg on cisplatin (CP)-induced neurotoxicity in rats.METHODS:
Twenty eight rats were randomly distributed into four groups. The first group was kept as a control. In the second group, CP was given at the single dose of 7 mg/kg intraperitoneally. In the third group, βg was orally administered at the dose of 50 mg/kg/day for 14 days. In the fourth group, CP and βg were given together at the same doses.RESULTS:
CP treatment caused significant oxidative damage via induction of lipid peroxidation and reductions antioxidant defense system potency in the brain tissue. In addition, histopathological damage increased with CP treatment. On the other hand, βg treatment largely prevented oxidative and histopathological negative effects of CP.CONCLUSIONS:
Cisplatin has severe neurotoxic effects in rats and βg supplementation has significant beneficial effects against CP toxicity depending on its antioxidant properties. Thus, it appears that βg might be useful against CP toxicity in patients with cancer in terms of nervous system.(AU)Palavras-chave
Texto completo:
1
Base de dados:
VETINDEX
Assunto principal:
Compostos de Platina
/
Estresse Oxidativo
/
Beta-Glucanas
/
Agentes Neurotóxicos
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras.
Ano de publicação:
2016
Tipo de documento:
Article