The role of oxymatrine in regulating TGF-beta1 in rats with hepatic fibrosis
Acta cir. bras.
; 33(3): 207-215, mar. 2018. tab, ilus, graf
Article
em En
| VETINDEX
| ID: vti-19583
Biblioteca responsável:
BR68.1
ABSTRACT
Purpose:
To investigate whether oxymatrine (OMT) prevents hepatic fibrosis in rats by regulating liver transforming growth factor β1 (TGF-β1) level.Methods:
Hepatic fibrosis was induced in rats by thioacetamide (TAA). Blood was collected at the end of week 12 to determine the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutathione (GSH). Changes in liver tissue were observed after hematoxylin-eosin (HE) staining.Results:
Fibrosis was confirmed by Massons collagen staining. Liver TGF-β1 level was determined by ELISA. OMT significantly reduced serum ALT and AST but increased GSH levels in rats with hepatic fibrosis. Moreover, it significantly improved liver histology in rats with TAA-induced hepatic fibrosis. It significantly decreased liver TGF-β1 level compared to that in the untreated group. It also significantly reduced collagen deposition in rats.Conclusion:
Oxymatrine is effective in protecting rats from thioacetamide-induced hepatic fibrosis by regulating TGF-β1 expression.(AU)Palavras-chave
Texto completo:
1
Base de dados:
VETINDEX
Assunto principal:
Compostos Químicos
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Prevenção de Doenças
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Fator de Crescimento Transformador beta1
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Cirrose Hepática
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras.
Ano de publicação:
2018
Tipo de documento:
Article
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Project document