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DNA damage in Wistar Kyoto rats exercised during pregnancy
Corrêa, Mikaela da Silva; Gelaleti, Rafael Bottaro; Bento, Giovana Fernanda; Damasceno, Débora Cristina; Peraçoli, José Carlos.
Afiliação
  • Corrêa, Mikaela da Silva; Universidade Estadual Paulista. Botucatu Medical School. Department of Gynecology and Obstetrics. Laboratory of Experimental Research in Gynecology and Obstetrics. Botucatu. Brazil
  • Gelaleti, Rafael Bottaro; Universidade Estadual Paulista. Botucatu Medical School. Department of Gynecology and Obstetrics. Laboratory of Experimental Research in Gynecology and Obstetrics. Botucatu. Brazil
  • Bento, Giovana Fernanda; Universidade Estadual Paulista. Botucatu Medical School. Botucatu. Brazil
  • Damasceno, Débora Cristina; Universidade Estadual Paulista. Botucatu Medical School. Department of Gynecology and Obstetrics. Laboratory of Experimental Research in Gynecology and Obstetrics. Botucatu. Brazil
  • Peraçoli, José Carlos; Universidade Estadual Paulista. Botucatu Medical School. Department of Gynecology and Obstetrics. Laboratory of Experimental Research in Gynecology and Obstetrics. Botucatu. Brazil
Acta cir. bras. ; 32(5): 388-395, May 2017. tab, graf
Article em En | VETINDEX | ID: vti-17630
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

Purpose:

To evaluate DNA damage levels in pregnant rats undergoing a treadmill exercise program.

Methods:

Wistar Kyoto rats were allocated into two groups (n= 5 animals/group) non-exercise and exercise. The pregnant rats were underwent an exercise protocol on a treadmill throughout pregnancy. Exercise intensity was set at 50% of maximal capacity during maximal exercise testing performed before mating. Body weight, blood pressure and glucose levels, and triglyceride concentration were measured during pregnancy. At day 10 post-natal, the animals were euthanized and maternal blood samples were collected for DNA damage.

Results:

Blood pressure and glucose levels and biochemical measurements showed no significant differences. Increased DNA damage levels were found in exercise group compared to those of non-exercise group (p 0.05).

Conclusion:

The exercise intensity protocol used in the study might have been exhaustive leading to maternal increased DNA damage levels, demonstrating the relevance of an adequate protocol of physical exercise.(AU)
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Texto completo: 1 Base de dados: VETINDEX Assunto principal: Dano ao DNA / Gravidez / Exercício Físico / Teste de Esforço Limite: Animals / Pregnancy Idioma: En Revista: Acta cir. bras. Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Dano ao DNA / Gravidez / Exercício Físico / Teste de Esforço Limite: Animals / Pregnancy Idioma: En Revista: Acta cir. bras. Ano de publicação: 2017 Tipo de documento: Article