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Low-energy shock wave preconditioning reduces renal ischemic reperfusion injury caused by renal artery occlusion
Xue, Yuquan; Xu, Zhibin; Chen, Haiwen; Gan, Weimin; Chong, Tie.
Afiliação
  • Xue, Yuquan; Xian Jiaotong University. the Second Affiliated Hospital. Department of Urology. Shaanxi Province. China
  • Xu, Zhibin; Xian Jiaotong University. the Second Affiliated Hospital. Department of Urology. Shaanxi Province. China
  • Chen, Haiwen; Xian Jiaotong University. the Second Affiliated Hospital. Department of Urology. Shaanxi Province. China
  • Gan, Weimin; Xian Jiaotong University. the Second Affiliated Hospital. Department of Urology. Shaanxi Province. China
  • Chong, Tie; Xian Jiaotong University. the Second Affiliated Hospital. Department of Urology. Shaanxi Province. China
Acta cir. bras. ; 32(7): 550-558, July 2017. ilus, tab
Article em En | VETINDEX | ID: vti-17587
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

Purpose:

To evaluate whether low energy shock wave preconditioning could reduce renal ischemic reperfusion injury caused by renal artery occlusion.

Methods:

The right kidneys of 64 male Sprague Dawley rats were removed to establish an isolated kidney model. The rats were then divided into four treatment groups Group 1 was the sham treatment group; Group 2, received only low-energy (12 kv, 1 Hz, 200 times) shock wave preconditioning; Group 3 received the same low-energy shock wave preconditioning as Group 2, and then the left renal artery was occluded for 45 minutes; and Group 4 had the left renal artery occluded for 45 minutes. At 24 hours and one-week time points after reperfusion, serum inducible nitric oxide synthase (iNOS), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), creatinine (Cr), and cystatin C (Cys C) levels were measured, malondialdehyde (MDA) in kidney tissue was detected, and changes in nephric morphology were evaluated by light and electron microscopy.

Results:

Twenty-four hours after reperfusion, serum iNOS, NGAL, Cr, Cys C, and MDA levels in Group 3 were significantly lower than those in Group 4; light and electron microscopy showed that the renal tissue injury in Group 3 was significantly lighter than that in Group 4. One week after reperfusion, serum NGAL, KIM-1, and Cys C levels in Group 3 were significantly lower than those in Group 4.

Conclusion:

Low-energy shock wave preconditioning can reduce renal ischemic reperfusion injury caused by renal artery occlusion in an isolated kidney rat model.(AU)
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Texto completo: 1 Base de dados: VETINDEX Assunto principal: Ratos / Traumatismo por Reperfusão / Isquemia Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Ratos / Traumatismo por Reperfusão / Isquemia Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2017 Tipo de documento: Article