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Clotting Factor XIII and desmopressin improve hemostasis in uncontrolled bleeding
Carreiro, Paulo Roberto Lima; Rezende-Neto, João Baptista; Lisboa, Thiago de Assis; Ribeiro, Daniel Dias; Camargos, Elizabeth Ribeiro da Silva; Andrade, Marcus Viniciius de Melo; Rizoli, Sandro Baletotti; Melo, José Renan da Cunha.
Afiliação
  • Rezende-Neto, João Baptista; University of Toronto. Toronto. Canada
  • Lisboa, Thiago de Assis; Universidade Federal de Minas Gerais. Belo Horizonte. Brasil
  • Ribeiro, Daniel Dias; Universidade Federal de Minas Gerais. Belo Horizonte. Brasil
  • Camargos, Elizabeth Ribeiro da Silva; Universidade Federal de Minas Gerais. Belo Horizonte. Brasil
  • Andrade, Marcus Viniciius de Melo; University of Toronto. Toronto. Canada
  • Rizoli, Sandro Baletotti; University of Toronto. Toronto. Canada
  • Melo, José Renan da Cunha; Universidade Federal de Minas Gerais. Belo Horizonte. Brasil
Acta cir. bras. ; 30(3): 170-177, 2015.
Article em En | VETINDEX | ID: vti-12022
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

PURPOSE:

To investigate hemostatic effects of supplementary factor XIII and desmopressin (DDAVP) in resuscitation of uncontrolled bleeding.

METHODS:

Fifty-four rabbits were randomized in nine groups G1 Sham; G2 FXIII and normotensive resuscitation (NBP); G3 FXIII and permissive hypotension (PH) (MAP 60% baseline); G4 FXIII/DDAVP/NBP; G5 FXIII/DDAVP/PH; G6 NBP only; G7 FXIII no hemorrhage; G8 FXIII/DDAVP no hemorrhage; G9 PH only. Thromboelastometry and intra-abdominal blood loss were assessed. Scanning electron microscopy (EM) of the clots was performed.

RESULTS:

Compared to Sham, only G8 (FXIII/DDAVP w/o hemorrhage) showed clotting time (CT) significantly lower (p<0.05). NBP alone (G6) resulted in significantly prolonged CT compared to G2, G3 and G5 (p<0.05). Similarly, median alpha angle was significantly larger in G3,4,5, and 9 compared to G6 (p<0.05). Area under the curve was significantly greater in G5 than G2. Intra-abdominal blood loss was lower in G5 and G9 compared to G2 and G6. FXIII/DDAVP and PH resulted in more robust fibrin mesh by EM.

CONCLUSIONS:

Normotensive resuscitation provokes more bleeding and worsens coagulation compared to pH, that is partially reversed by factor XIII and desmopressin. FXIII and DDAVP can synergistically improve coagulation. Permissive hypotension reduces bleeding regardless of those agents.(AU)
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Texto completo: 1 Base de dados: VETINDEX Assunto principal: Coelhos / Coagulação Sanguínea / Hemorragia / Hemostasia Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Base de dados: VETINDEX Assunto principal: Coelhos / Coagulação Sanguínea / Hemorragia / Hemostasia Limite: Animals Idioma: En Revista: Acta cir. bras. Ano de publicação: 2015 Tipo de documento: Article