Mild reproductive effects of the Tityus bahiensis scorpion venom in rats
J. Venom. Anim. Toxins incl. Trop. Dis.
; 20: 1-9, 2014. ilus, tab, graf
Article
em En
| VETINDEX
| ID: vti-10964
Biblioteca responsável:
BR68.1
Localização: BR68.1
ABSTRACT
Scorpion envenoming is a public health problem in Brazil, where Tityus serrulatus and T. bahiensis are considered the most dangerous scorpions. They are well adapted to urbanized environments, and there is an increasing probability of human exposure to these venoms, including during pregnancy. Not much is known about the effects of prenatal exposure to the venom, and no information is available to aid in the rational treatment of victims stung during pregnancy. Thus, this study aimed to investigate whether venom from the scorpion T. bahiensis administered once to pregnant female rats at a dose that causes a moderate envenomation may lead to deleterious effects on the reproductive performance of the dams and on the development of their offspring. This is the first work demonstrating that T. bahiensis venom, when administered experimentally to rats, alters maternal reproductive performance and the morphological development of fetuses. The venom was given to dams on the 5th (GD5) or on the 10th (GD10) gestational day. After laparotomy, on GD21, fetuses and placentas were counted, weighed and externally analyzed. The corpora lutea were counted. The sex and vitality of fetuses were evaluated, and each litter was then randomly divided for visceral or skeletal analyses. Data were analyzed by ANOVA followed by the Tukey-Kramer test and Fisher's exact test. The significance level for all tests was set at p < 0.05.(AU)
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
VETINDEX
/
LILACS
Assunto principal:
Ratos
/
Venenos de Escorpião
/
Prenhez
Limite:
Animals
Idioma:
En
Revista:
J. Venom. Anim. Toxins incl. Trop. Dis.
/
J. venom. anim. toxins incl. trop. dis
Assunto da revista:
TOXICOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil