Oxidative stress and fatty acid profile in Wistar rats subjected to acute food restriction and refeeding with high-fat diets
Acta cir. bras.
; 29(3): 178-185, 03/2014. tab, graf
Article
em En
| VETINDEX
| ID: vti-10214
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BR1.1
Localização: BR68.1
ABSTRACT
To assess oxidative stress and the profile of fatty acids incorporated into the hepatic tissue of animals refed with high-fat (HF) diets after acute food restriction. METHODS:
Fifty male Wistar rats were divided into five groups and fasting for 48 hours. One group was sacrificed without refeeding (NR), a control group (C) was refed with the standard AIN-93 diet and the remaining groups with HF diets respectively consisting of hydrogenated vegetable oil (PHVO), trans-free (TF) margarine and trans-free margarine enriched with ω-3 and ω-6 (O). After this period the animals were sacrificed for malondialdehyde (MDA), catalase and hepatic fatty acid determination.RESULTS:
The groups refed with HF diets showed elevation of MDA levels compared to the C group (p<0.001 for GVH and p<0.01 for TF and O). Hepatic catalase activity was higher in the TF and O groups compared to group C (p<0.05 for both). The amount of saturated fatty acids was lower in the PHVO and O groups compared to the remaining ones (p<0.001).CONCLUSION:
The consumption of high-fat diets after prolonged fasting favors oxidative imbalance in hepatic tissue.(AU)Palavras-chave
Texto completo:
1
Base de dados:
VETINDEX
Assunto principal:
Estresse Oxidativo
/
Dieta
/
Gorduras
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras.
Ano de publicação:
2014
Tipo de documento:
Article