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Molecular analysis of HIV-1 infection in Barbados
Gittens, M; Roth, Walter E; Roach, Timothy C; Fraser, Henry S; Bond, V. C; Levett, Paul N.
Afiliação
  • Gittens, M; University of the West Indies, Cave Hill, Barbados. School of Clinical Medicine and Research
  • Roth, Walter E; University of the West Indies, Cave Hill, Barbados. School of Clinical Medicine and Research
  • Roach, Timothy C; University of the West Indies, Cave Hill, Barbados. School of Clinical Medicine and Research
  • Fraser, Henry S; University of the West Indies, Cave Hill, Barbados. School of Clinical Medicine and Research
  • Bond, V. C; Moreland School of Medicine, Atlanta, USA
  • Levett, Paul N; Moreland School of Medicine, Atlanta, USA
West Indian med. j ; West Indian med. j;49(Suppl 2): 3, Apr. 2000.
Article em En | MedCarib | ID: med-996
Biblioteca responsável: JM3.1
Localização: JM3.1; R18.W4
ABSTRACT

OBJECTIVE:

To determine the sub-type(s) of HIV-1 in patients with advanced disease in Barbados. DESIGN AND

METHODS:

A molecular analysis was performed in sequences obtained from 38 HIV-1 infected persons. A 375 base pair fragment was amplified from the V3 loop of the env region of the HIV genome, using a nested RT-PCR method. The resulting fragment was sequenced directly and alignment was performed using the BLAST (Basic Local Alignment Search Tool) search.

RESULTS:

Of 38 patients with advanced HIV-1 infection, all were found to be infected with HIV-1 subtype B, which closely relates to a similar subtype found in North America and Europe. This is the first time that HIV subtypes have been described from Barbadian patients with advanced HIV disease.

CONCLUSIONS:

Our findings support the hypothesis that HIV infection in Barbados was derived initially from North America and Europe, where type B HIV infection is most common. Moreover, these findings indicate that vaccines suitable for use in North America will probably be effective in our population.(Au)
Assuntos
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Coleções: 01-internacional Base de dados: MedCarib Assunto principal: Síndrome da Imunodeficiência Adquirida / Epidemiologia Molecular Limite: Humans País/Região como assunto: Barbados / Caribe ingles Idioma: En Revista: West Indian med. j Ano de publicação: 2000 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MedCarib Assunto principal: Síndrome da Imunodeficiência Adquirida / Epidemiologia Molecular Limite: Humans País/Região como assunto: Barbados / Caribe ingles Idioma: En Revista: West Indian med. j Ano de publicação: 2000 Tipo de documento: Article