Coagulase-negative staphylococcal bacteremia in severely malnourished Jamaican children
Pediatr Infect Dis J
; 11(12): 1030-6, Dec. 1992.
Article
em En
| MedCarib
| ID: med-8508
Biblioteca responsável:
JM3.1
Localização: JM3.1; RJ401.P4
ABSTRACT
Immunosupression increases the susceptibility to infection and changes the inflammatory response in children with severe protein-energy malnutrition. In this 5-year prospective study bacteremia was documented in 16 percent of the 336 severely malnourished children, 2 to 34 months of age, who were hospitalized consecutively in the Tropical Metabolism Research Unit, Kingston, Jamaica. The 53 children had 60 episodes of nosocomial and community-acquired bacteremia with 69 blood isolates. Community-acquired bacteremia accounted for 72 percent (43 of 60) of bactermic episodes. Thirty-five percent (24 of 69) of the strains were coagulase-negative staphylococci, 19 percent (13 of 69) were Staphylococcus aureus and 11 percent (8 of 69) were Streptococcus Group D. Seventeen episodes of coagulase negative staphylococcal bacteremia were acquired in the community and 7 nosocominal. These patients were more likely to have pneumonic consolidation than children with all other bacteremias combined (p < 0.02, Fisher's exact test). The bacteremia-related case fatality rate was 8 percent (5 of 60). Polymicrobial and Gram-negative septicemia were independent positive predictive factors for mortality when compared with single-agent and Gram-positive sepsis (P < 0.02). This 71 percent (49 of 69) prevalence of Gram-positive organism suggests a change in the epidemiology from the predominant Gram-negative etiologies (76 percent) described in previous reports (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Infecções Estafilocócicas
/
Desnutrição Proteico-Calórica
/
Sepse
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Caribe ingles
/
Jamaica
Idioma:
En
Revista:
Pediatr Infect Dis J
Ano de publicação:
1992
Tipo de documento:
Article