Role of HTLV-I in development of non-Hodgkin lymphoma in Jamaica and Trinidad and Tobago. The HTLV lymphoma study group
Lancet
; 342(8885): 1447-50, Dec. 11 1993.
Article
em En
| MedCarib
| ID: med-8338
Biblioteca responsável:
JM3.1
Localização: JM3.1; R31.L3
ABSTRACT
Human T-cell lymphotropic virus type I (HTLV-I) has been implicated in the aetiology of adult T-cell leukaemia/lymphoma in Japan and elsewhere, particularly the Caribbean. We have carried out parallel case-control studies in Jamaica and in Trinidad and Tobago to quantify the role of HTLV-I in the development of non-Hodgkin lymphoma (NHL). 135 cases of NHL were enroled in Jamaica and 104 in Trinidad and Tobago. Controls were selected from patients treated in the same wards or clinics at the same time as the cases. Overall, patients with NHL were 10 times more likely than were controls to be seropositive for HTLV-I (Jamaica odds ratio 10.3 [95 percent CI 6.0-18.0], Trinidad and Tobago 14.4 [7.6-27.2]). In both countries the association between NHL and HTLV-I was greatest for T-cell lymphomas (18.3 [9.5-35.6] and 63.3 [25-267]). Among T-cell lymphomas especially, there was no significant difference between men and women in the association between NHL and HTLV-I, but there was a significant inverse relation between age and likelihood of HTLV-I seropositivity. B-cell lymphomas were predominant in the older age groups and were not associated with HTLV-I seropositivity. These findings are consistent with the hypothesis that early life exposure to HTLV-I is important for risk of subsequent ATL. Prevention of vertical transmission of HTLV-I could reduce by 70-80 percent cases of NHL in people under 60 years in this region (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Linfoma não Hodgkin
/
Vírus Linfotrópico T Tipo 1 Humano
/
Anticorpos Anti-HTLV-I
/
Leucemia-Linfoma de Células T do Adulto
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Caribe ingles
/
Jamaica
/
Trinidad y tobago
Idioma:
En
Revista:
Lancet
Ano de publicação:
1993
Tipo de documento:
Article