Assay of folic acid deficiency in man
West Indian med. j
; 11(2): 134, June 1962.
Article
em En
| MedCarib
| ID: med-7545
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
Three newer techniques for the assay of folic acid deficiency in man were evaluated and compared with the other method of employing the hematological response to physiological doses of folic acid. (1) The urinary formiminoglutamic acid (FIGLU) output before and after a histidine metabolic load correlated with clinical folic acid deficiency and with the therapeutic response to physiological doses of folic acid. (2) The plasma clearance of folic acid activity after a 15 ug/Kg B.W. doses of folic acid intravenously correlated with clinic folic acid deficiency in nutritional macrocytic anaemia and the malabsorption syndromes. It was not as useful in pregnancy and the chronic hemolytic anaemias. (3) The fasting serum folic acid activity level as measured by the L. casei microbiological assay was a useful index for clinical folic acid deficiency in macrocytic anaemia associated with malnutrition in the adult and in those with gastro-intestinal malabsorption syndromes. In the infant the range of serum levels was wide and many with clinical folic acid deficiency had levels in the normal range. In combined B12 and folic acid deficiencies, normal or elevated values for the plasma clearance and folic acid serum level, masked an underlying folic acid deficiency (AU)
Buscar no Google
Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Deficiência de Ácido Fólico
Limite:
Humans
Idioma:
En
Revista:
West Indian med. j
Ano de publicação:
1962
Tipo de documento:
Article
/
Congress and conference