Immunization of the premature newborn - abstract
West Indian med. j
; West Indian med. j;32(Suppl): 15, 1983.
Article
em En
| MedCarib
| ID: med-6159
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
The human immune system is not fully competent at the time of birth and is even more immature with earlier gestational age at delivery. Nothing is known about the ability of the immune system of the premature newborn to respond to immunization. We are studying the immune response of prematures at Mt. Hope Maternity Hospital, Trinidad to determine the optimal time of immunization. Neonates are divided into four groups based on birth weight. Each group is further subdivided into two subgroups, one immunized 6-8 weeks after birth and the other at 6-8 weeks after calculated full term. Immunization includes diphtheria, pertussis, tetanus and polio. Immune response is measured by tetanus toxoid antibody and cellular reponses. To date, 50 neonates have been entered into the study. Thirty-nine have completed the primary series of three immuniations and 27 have had at least one follow-up sample. Twelve of the neonate were less than 1500/gm at birth. Eleven of the 12 have had appropriate antibody responses. The baby who did not respond had a high titre of passive maternal antibody at birth (4.2 i.u./ml) and the absence of reponse may be related to this. No differences in reponses habe been observed with early and late immunization. Cellular responses to tetanus toxoid were variable. Forty-two per cent of babies showed in-vitro reativity to tetanus at birth. However, only 30 per cent were reactive following the primary immunization series. Responses to streptococcal antigens fluctuated with the tetanus reponses, suggesting no specificity in the blastogenic response in these neonates (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Recém-Nascido
/
Recém-Nascido Prematuro
/
Imunização
Limite:
Humans
/
Newborn
País/Região como assunto:
Caribe ingles
/
Trinidad y tobago
Idioma:
En
Revista:
West Indian med. j
Ano de publicação:
1983
Tipo de documento:
Article
/
Congress and conference