Cerebrospinal fluid C-reactive protein in the laboratory diagnosis of bacterial meningitis - abstract
West Indian med. j
; West Indian med. j;33(Suppl): 30, 1984.
Article
em En
| MedCarib
| ID: med-6081
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
Samples of cerebrospinal fluid (CSF) from 112 cases of suspected meningitis were tested fo the presence of C-reative protein (CRP) using a qualitative and quantitative slide test. Bacterial meningitis was confirmed in 34 patients based on CSF and blood culture results and/or elevated CSF white blood cell (WBC) count and typical CSF biochemical profile. There were eight patients with early onset and 3 who had received prior antimierobial therapy among the 5 neonates, 23 children, and 6 adults with bacterial meningitis. Organisms recovered from CSF and/or blood included Haemophilus influenzae (14), Strptococcus pneumoniae (9), Streptococcus group B (5), Staphylococcus aureus (2), E. coli (2) and Klebsiella pneumoniae (1). Slide test was positive for CRP in 33 cases, giving a sensitiviy of 97 percent which compare favourably with elevated CSF protein (33 percent), decreased CSF glucose (64.7 percent), CSF glucose/blood glucose 1/2 (85 percent), raised CSF WBC (38.2 percent), raised CSF PMN (61.7 percent), CSF PMN culture positive (88.2 percent) and CSF gram stain positive (82.5 percent). Slide test was positive for CRP in 1 of 7 CSF samples which were negative for bacterial meningitis, giving a specificity of 98 percent). It is concluded that testing of CSF for CRP is a simple, rapid and accurate method for the laboratory diagnosis of bacterial meningitis, which is particularly appropriate for areas lacking adequate laboratory facilities (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Proteínas do Líquido Cefalorraquidiano
/
Meningites Bacterianas
Tipo de estudo:
Diagnostic_studies
/
Qualitative_research
Limite:
Adult
/
Child
/
Humans
/
Infant
Idioma:
En
Revista:
West Indian med. j
Ano de publicação:
1984
Tipo de documento:
Article
/
Congress and conference