Relationship of glucose intolerance to coronary risk in Afro-Caribbeans compared with Europeans
Diabetologia
; 37(8): 765-72, Aug. 1994.
Article
em En
| MedCarib
| ID: med-5865
Biblioteca responsável:
JM3.1
Localização: JM3.1; RC660.A1D53
ABSTRACT
Afro-Caribbeans have low mortality rates from coronary heart disease, despite a high prevalence of diabetes mellitus. We examined 1166 Afro-Caribbean and European men and women aged 40-64 years in a community survey in London, UK. Prevalence of glucose intolerance (combining impaired glucose tolerance, new and known diabetes) was 31 percent in Afro-Caribbeans and 14 percent in Europeans (p<0.001). In men, the prevalence of probable coronary heart disease was 6 percent in Afro-Caribbeans and 13 percent in Europeans (p<0.01). Triglyceride was lower in Afro-Caribbeans than Europeans; in men, HDL cholesterol was higher. Afro-Caribbeab men were less centrally obese, while Afro-Caribbean women were more centrally obese than their European counterparts. Fasting and 2-h insulin levels were higher in Afro-Caribbeans than Europeans. Glucose intolerance was associated with high triglyceride, low HDL cholesterol and central obesity in European but not in Afro-Caribbean men. In Europeans, fasting triglyceride was 1.49 mmol/l in normoglycaemic and 1.89 mmol/l in glucose intolerant men (p<0.05), in Afro-Caribbean men triglyceride was 1.08 and 1.22 mmol/l, respectively. Waist hip ratio was 0.94 in normoglycaemic, and 0.98 in glucose intolerant European men (p<0.001). In Afro-Caribbean men, waist hip ratio was 0.93 in both groups. At each level of insulin, glucose or central obesity, triglyceride was lower in Afro-Caribbean men and women than in Europeans. We speculate that despite high insulin levels, Afro-Caribbeans have a favourable lipoprotein pattern which persists in the presence of glucose intolerance, and may be related to body fat distribution. This could begin to explain their low rates of coronary heart disease (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Intolerância à Glucose
/
Doença das Coronárias
Tipo de estudo:
Etiology_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Diabetologia
Ano de publicação:
1994
Tipo de documento:
Article